dc.citation.conferencePlace |
KO |
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dc.citation.conferencePlace |
제주 |
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dc.citation.title |
제 129회 대한화학회 학술발표회 |
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dc.contributor.author |
Lee, Jeong Woo |
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dc.contributor.author |
Hong, Sung You |
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dc.date.accessioned |
2024-01-31T20:38:32Z |
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dc.date.available |
2024-01-31T20:38:32Z |
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dc.date.created |
2022-07-08 |
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dc.date.issued |
2022-04-15 |
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dc.description.abstract |
α,β-Unsaturated ketones are widely used as raw materials in the production of fine chemicals, medicines, and natural products. Through chemoselective aldehydic C–H activation, transition metal-catalyzed hydroacylation processes of alkynes employing aldehydes have been recognized as an atom-economical method to access, unsaturated ketones. However, chelating moiety-bearing aldehydes are required in previously described hydroacylation reactions utilizing rhodium, cobalt, or ruthenium catalysts to prevent decarbonylation of acyl-metal-hydride complexes. In the presence of zinc metal as a reducing agent, we present a nickel-catalyzed anti-Markovnikov selective coupling process that yields non-tethered E-enones from terminal alkynes and S-2-pyridyl thioesters. This method, which is not chelation-controlled, has mild reaction conditions and excellent regio- and stereoselectivity. |
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dc.identifier.bibliographicCitation |
제 129회 대한화학회 학술발표회 |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/76186 |
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dc.identifier.url |
https://new.kcsnet.or.kr/?mid=abstract_view&uid=62623&page=1&qpage=&word=ketonesthroughnickelcatalyzed&wordfield=subject&main_number=129 |
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dc.publisher |
대한화학회 |
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dc.title |
Approach to alpha,beta-unsaturated ketones through nickel catalyzed aldehyde-free hydroacylation |
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dc.type |
Conference Paper |
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dc.date.conferenceDate |
2022-04-13 |
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