dc.citation.conferencePlace |
KO |
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dc.citation.title |
TERMIS-AP 2022 |
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dc.contributor.author |
Lee, Kangseok |
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dc.contributor.author |
Noh, Yeongjin |
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dc.contributor.author |
Cha, Chaenyung |
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dc.date.accessioned |
2024-01-31T20:06:02Z |
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dc.date.available |
2024-01-31T20:06:02Z |
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dc.date.created |
2022-10-03 |
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dc.date.issued |
2022-10-07 |
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dc.description.abstract |
In situ forming hydrogels are widely explored as injectable drug delivery systems for biomedical applications. It is important for these hydrogels to undergo gelation and deliver the drug in a timely manner upon administration. In this study, lysine-rich elastin-like polypeptide (ELP) and aldehyde-presenting alginate are crosslinked via Schiff base formation under ambient conditions to generate hydrogel. The physicomechanical and drug release properties of the alginate-ELP hydrogel are conveniently controlled by the concentrations of alginate and ELP. Furthermore, due to the thermoresponsiveness of ELP, the alginate-ELP hydrogel undergoes reversible swelling/deswelling at the transition temperature near the physiological temperature. Therefore, the drug release from the alginate-ELP hydrogel is expedited via thermoresponsive deswelling. Taken together, the in situ forming alginate-ELP hydrogel is a highly attractive injectable drug delivery system capable of programmable release characteristics. |
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dc.identifier.bibliographicCitation |
TERMIS-AP 2022 |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/75426 |
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dc.publisher |
TERMIS-AP |
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dc.title |
In situ forming elastin-like polypeptide hydrogel for injectable drug delivery applications |
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dc.type |
Conference Paper |
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dc.date.conferenceDate |
2022-10-05 |
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