dc.citation.conferencePlace |
KO |
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dc.citation.title |
130th General Meeting of the Korean Chemical Society |
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dc.contributor.author |
Gandra, Upendar Reddy |
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dc.contributor.author |
Oh, Jun Yong |
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dc.contributor.author |
Sim, Youjung |
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dc.contributor.author |
Ryu, Ja-Hyoung |
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dc.date.accessioned |
2024-01-31T19:40:53Z |
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dc.date.available |
2024-01-31T19:40:53Z |
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dc.date.created |
2022-10-27 |
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dc.date.issued |
2022-10-20 |
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dc.description.abstract |
Organelle-targeted light-controlled drug release as well as formation of self-assembled structures system for regulating the cellular fate of cancer cells is an emerging as a potent cancer therapeutic strategy.1 Achieving the NO-release as well as self-assembly of amphiphilic NO-prodrug inside a cell or cellular organelle with external stimuli is not reported due to the several challenges. Nitric oxide (NO), a diatom radical, has been recognized as the first signaling molecule, playing critical roles in in human body.2,3 A precise spatial and temporal control over the NO-release is the major requirement in clinical applications.4 Here, we have synthesized an amphiphilic N-nitrosamine having fluorescent molecule (A). The introduction of N-nitrosamine moieties efficiently inhibits the molecular interactions of A before NO-release. Under light irradiation, A releases NO followed by self-assembly via formation of J-aggregates with a remarkable bathochromic shift of ~30 nm. A is very stable under dark conditions, NO-release was effectively triggered using low power low energy wavelength irradiation (800 nm, ≤28 mW). The biological influence of light induced NO-release as well as self-assembly nature of A in vitro studies are under progress. |
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dc.identifier.bibliographicCitation |
130th General Meeting of the Korean Chemical Society |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/75367 |
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dc.identifier.url |
http://new.kcsnet.or.kr/?mid=abstract_view&uid=65693&page=1&qpage=&word=Gandra&wordfield=author&main_number=130 |
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dc.publisher |
Korean Chemical Society |
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dc.title |
Light-controlled dual-functional amphiphilic probe with NO-release and simultaneous intramitochondrial self-assembly of nanostructures for supramolecular cancer therapeutics |
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dc.type |
Conference Paper |
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dc.date.conferenceDate |
2022-10-19 |
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