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Cho, Hyungjoon
Biomedical Imaging Science and Engineering Lab(BISE)
Research Interests
  • Imaging tumor microenvironments, susceptibility contrast based MR structural imaging, ultra fast acquisitions of dynamic MR, algorithm/Hardware development for magnetic particle imaging

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Diffusion-based MR methods for bone structure and evolution

Cited 19 times inthomson ciCited 18 times inthomson ci
Title
Diffusion-based MR methods for bone structure and evolution
Author
Sigmund, E. E.Cho, HyungjoonChen, P.Byrnes, S.Song, Y. -Q.Guo, X. E.Brown, T. R.
Keywords
DDIF; Diffusion; Internal field gradient; Surface-to-volume ratio; Trabecular bone
Issue Date
2008-01
Publisher
WILEY-BLACKWELL
Citation
MAGNETIC RESONANCE IN MEDICINE, v.59, no.1, pp.28 - 39
Abstract
A new approach to MR trabecular bone characterization is presented. This method probes the diffusion of spins through internal magnetic field gradients due to the susceptibility contrast between the bone and water (or marrow) phases. The resulting spin magnetization decay encodes properties of the underlying structure. This method, termed decay due to diffusion in the internal field (DDIF), is well established as a probe of pore size and structure. In the present work its application is shown for in vitro experiments on excised bovine tibiae samples. A comparison with pulsed field gradient (PFG) measurement of restricted diffusion shows a strong correlation of DDIF with the surface-to-volume ratio (SVR) of bones. Calculation of the internal magnetic field within the bone structure also supports this interpretation. These NMR measurements compare well with the image analysis from microscopic computed tomography (μCT). The SVR is not accessible in the clinically standard densitometry measurements, and provides vital information on bone strength and therefore on its fracture risk. The DDIF and PFG methods derive this information from a straightforward pulse sequence that does not employ either high applied field gradients or microimaging, and thus may have clinical potential.
URI
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DOI
10.1002/mrm.21281
ISSN
0740-3194
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BME_Journal Papers
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