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Choi, Jang Hyun
Lab of Diabetes and Metabolism Lab.
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dc.citation.endPage 468 -
dc.citation.number 7382 -
dc.citation.startPage 463 -
dc.citation.title NATURE -
dc.citation.volume 481 - Bostroem, Pontus - Wu, Jun - Jedrychowski, Mark P. - Korde, Anisha - Ye, Li - Lo, James C. - Rasbach, Kyle A. - Bostroem, Elisabeth Almer - Choi, Jang Hyun - Long, Jonathan Z. - Kajimura, Shingo - Zingaretti, Maria Cristina - Vind, Birgitte F. - Tu, Hua - Cinti, Saverio - Hojlund, Kurt - Gygi, Steven P. - Spiegelman, Bruce M. - 2023-12-22T05:37:01Z - 2023-12-22T05:37:01Z - 2014-10-14 - 2012-01 -
dc.description.abstract Exercise benefits a variety of organ systems in mammals, and some of the best-recognized effects of exercise on muscle are mediated by the transcriptional co-activator PPAR-gamma co-activator-1 alpha (PGC1-alpha). Here we show in mouse that PGC1-alpha expression in muscle stimulates an increase in expression of FNDC5, a membrane protein that is cleaved and secreted as a newly identified hormone, irisin. Irisin acts on white adipose cells in culture and in vivo to stimulate UCP1 expression and a broad program of brown-fat-like development. Irisin is induced with exercise in mice and humans, and mildly increased irisin levels in the blood cause an increase in energy expenditure in mice with no changes in movement or food intake. This results in improvements in obesity and glucose homeostasis. Irisin could be therapeutic for human metabolic disease and other disorders that are improved with exercise. -
dc.identifier.bibliographicCitation NATURE, v.481, no.7382, pp.463 - 468 -
dc.identifier.doi 10.1038/nature10777 -
dc.identifier.issn 0028-0836 -
dc.identifier.scopusid 2-s2.0-84862776702 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000299471800031 -
dc.language 영어 -
dc.title A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis -
dc.type Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus SKELETAL-MUSCLE -
dc.subject.keywordPlus ADIPOSE-TISSUE -
dc.subject.keywordPlus EXERCISE -
dc.subject.keywordPlus PGC-1-ALPHA -
dc.subject.keywordPlus PROTECTS -
dc.subject.keywordPlus PHOSPHORYLATION -
dc.subject.keywordPlus COACTIVATOR -
dc.subject.keywordPlus EXPRESSION -
dc.subject.keywordPlus MYOBLAST -
dc.subject.keywordPlus DISEASE -


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