Cancer associated adipocyte promotes tumor progression via Fam3c

Abstract

Adipocyte near tumor region, called cancer associated adipocyte (CAA), support tumor progression. CAA promotes ovarian cancer metastasis and provide energy for rapid tumor growth and exhibits an activated phenotype and contribute to breast cancer invasion. Recently the causes of this phenomena are explained by several hypotheses that CAA promote tumor progression via increased inflammation, epithelial-mesenchymal transition, and angiogenesis. In this report, I found that Fam3c is overexpressed in CAA in in-vitro and in vivo system. I demonstrate that secreted Fam3c from CAA induce EMT gene expression and protein expression level in SW480 cell line. I also show that these results affect cancer cell migration and invasion in in vitro system. This study, therefore, has furthered our understanding of the association between cancer and CAA in the perspective of molecular biology.