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DC Field | Value | Language |
---|---|---|
dc.citation.number | 21 | - |
dc.citation.startPage | 218401 | - |
dc.citation.title | PHYSICAL REVIEW LETTERS | - |
dc.citation.volume | 131 | - |
dc.contributor.author | Mcbride, John M. | - |
dc.contributor.author | Polev, Konstantin | - |
dc.contributor.author | Abdirasulov, Amirbek | - |
dc.contributor.author | Reinharz, Vladimir | - |
dc.contributor.author | Grzybowski, Bartosz A. | - |
dc.contributor.author | Tlusty, Tsvi | - |
dc.date.accessioned | 2024-01-24T12:05:09Z | - |
dc.date.available | 2024-01-24T12:05:09Z | - |
dc.date.created | 2023-12-29 | - |
dc.date.issued | 2023-11 | - |
dc.description.abstract | AlphaFold2 (AF) is a promising tool, but is it accurate enough to predict single mutation effects Here, we report that the localized structural deformation between protein pairs differing by only 1-3 mutations - as measured by the effective strain - is correlated across 3901 experimental and AF-predicted structures. Furthermore, analysis of ∼11 000 proteins shows that the local structural change correlates with various phenotypic changes. These findings suggest that AF can predict the range and magnitude of single-mutation effects on average, and we propose a method to improve precision of AF predictions and to indicate when predictions are unreliable. | - |
dc.identifier.bibliographicCitation | PHYSICAL REVIEW LETTERS, v.131, no.21, pp.218401 | - |
dc.identifier.doi | 10.1103/PhysRevLett.131.218401 | - |
dc.identifier.issn | 0031-9007 | - |
dc.identifier.scopusid | 2-s2.0-85178462590 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/71796 | - |
dc.identifier.wosid | 001144853000004 | - |
dc.language | 영어 | - |
dc.publisher | American Physical Society | - |
dc.title | AlphaFold2 Can Predict Single-Mutation Effects | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Physics, Multidisciplinary | - |
dc.relation.journalResearchArea | Physics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | PROTEIN STRUCTURES | - |
dc.subject.keywordPlus | FLEXIBILITY | - |
dc.subject.keywordPlus | LANDSCAPE | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordPlus | SETS | - |
dc.subject.keywordPlus | NMR | - |
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