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Kim, Jeong Beom
Molecular Biomedicine Lab
Research Interests
  • Patient-specific stem cells, induced pluripotent stem (iPS) cells, direct conversion, 3D bio-printing, Regenerative medicine, Patient-specific drug screening


Induction of Pluripotency in Adult Unipotent Germline Stem Cells

DC Field Value Language Ko, Kinarm ko Tapia, Natalia ko Wu, Guangming ko Kim, Jeong Beom ko Arauzo-Bravo, Marcos J. ko Sasse, Philipp ko Glaser, Tamara ko Ruau, David ko Han, Dong Wook ko Greber, Boris ko Hausdoerfer, Kirsten ko Sebastiano, Vittorio ko Stehling, Martin ko Fleischmann, Bernd K. ko Bruestle, Oliver ko Zenke, Martin ko Schoeler, Hans R. ko 2014-10-13T01:26:48Z - 2014-10-10 ko 2009-07 -
dc.identifier.citation CELL STEM CELL, v.5, no.1, pp.87 - 96 ko
dc.identifier.issn 1934-5909 ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract Mouse and human stem cells with features similar to those of embryonic stem cells have been derived from testicular cells. Although pluripotent stem cells have been obtained from defined germline stem cells (GSCs) of mouse neonatal testis, only multipotent stem cells have been obtained so far from defined cells of mouse adult testis. In this study we describe a robust and reproducible protocol for obtaining germline-derived pluripotent stem (gPS) cells from adult unipotent GSCs. Pluripotency of gPS cells was confirmed by in vitro and in vivo differentiation, including germ cell contribution and transmission. As determined by clonal analyses, gPS cells indeed originate from unipotent GSCs. We propose that the conversion process requires a GSC culture microenvironment that depends on the initial number of plated GSCs and the length of culture time. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher CELL PRESS ko
dc.subject STEMCELL ko
dc.title Induction of Pluripotency in Adult Unipotent Germline Stem Cells ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-67649215189 ko
dc.identifier.wosid 000267879200013 ko
dc.type.rims ART ko
dc.description.wostc 118 *
dc.description.scopustc 121 * 2015-05-06 * 2014-10-10 *
dc.identifier.doi 10.1016/j.stem.2009.05.025 ko
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