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Bae, Sung Chul
Multiscale Optical Imaging Lab
Research Interests
  • Multiscale optical imaging, laser spectroscopy, laser microscopy, laser sensing, soft matter physics, surface and interfacial science, laser Matter Interaction


Vesicle Budding Induced by a Pore-Forming Peptide

DC Field Value Language Yu, Yan ko Vroman, Julie A. ko Bae, Sung Chul ko Granick, Steve ko 2014-10-10T01:57:06Z - 2014-10-08 ko 2010-01 ko
dc.identifier.citation JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.132, no.1, pp.195 - 201 ko
dc.identifier.issn 0002-7863 ko
dc.identifier.uri -
dc.description.abstract We describe, in a system whose uniqueness is that the presence of pores allows the volume to vary as budding proceeds, how phase separation on the surface of spheres extrudes material in the process called "budding". The system is giant phospholipid vesicles (GUVs) containing phase-separated regions of DOPC (soft, liquid) and DPPC (stiff, gel), with cholesterol and without it. Budding is triggered by adding the cationic pore-forming peptide, melittin. Without cholesterol, fluorescence experiments show that melittin selectively binds to the liquid domains, inducing them to form mainly exocytotic monodisperse smaller vesicle buds of this same material, causing the parent GUV to shrink. The effect of cholesterol is to produce just a few large buds following domain coalescence, rather than numerous smaller monodisperse ones. Line tension is experimentally shown to be essential for budding in this multicomponent membrane. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher AMER CHEMICAL SOC ko
dc.title Vesicle Budding Induced by a Pore-Forming Peptide ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-74849097759 ko
dc.identifier.wosid 000275084400050 ko
dc.type.rims ART ko
dc.description.wostc 28 *
dc.description.scopustc 29 * 2015-05-06 * 2014-10-08 *
dc.identifier.doi 10.1021/ja9059014 ko
dc.identifier.url ko
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