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- Suh, Pann-Ghill
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A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity
- Author(s)
- Choi, Sun-Sil, Kim, Eun Sun, Koh, Minseob, Lee, Soo-Jin, Lim, Donghyun, Yang, Yong Ryoul, Jang, Hyun-Jun, Seo, Kyung-ah, Min, Sang-Hyun, Lee, In Hee, Park, Seung Bum, Suh, Pann-Ghill, Choi, Jang Hyun
- Issued Date
- 2014-09
- Citation
- JOURNAL OF BIOLOGICAL CHEMISTRY, v.289, no.38, pp.26618 - 26629
- Abstract
- Background: PPARβ ligands can be used in numerous metabolic syndromes. Results: A novel non-agonist PPARβ ligand, UHC1 exhibited great beneficial effects on glucose metabolism and anti-inflammatory response. Conclusion: UHC1 shows anti-diabetic action by blocking CDK5-mediated PPARβ phosphorylation. Significance: UHC1 can be a novel therapeutic agent for use in type 2 diabetes and related metabolic disorders.
- Publisher
- AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
- ISSN
- 0021-9258
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