File Download

There are no files associated with this item.

  • Find it @ UNIST can give you direct access to the published full text of this article. (UNISTARs only)
Related Researcher

최장현

Choi, Jang Hyun
Lab of Diabetes and Metabolism Lab.
Read More

Views & Downloads

Detailed Information

Cited time in webofscience Cited time in scopus
Metadata Downloads

A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity

Author(s)
Choi, Sun-SilKim, Eun SunKoh, MinseobLee, Soo-JinLim, DonghyunYang, Yong RyoulJang, Hyun-JunSeo, Kyung-ahMin, Sang-HyunLee, In HeePark, Seung BumSuh, Pann-GhillChoi, Jang Hyun
Issued Date
2014-09
DOI
10.1074/jbc.M114.566794
URI
https://scholarworks.unist.ac.kr/handle/201301/6901
Fulltext
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84907203364
Citation
JOURNAL OF BIOLOGICAL CHEMISTRY, v.289, no.38, pp.26618 - 26629
Abstract
Background: PPARβ ligands can be used in numerous metabolic syndromes. Results: A novel non-agonist PPARβ ligand, UHC1 exhibited great beneficial effects on glucose metabolism and anti-inflammatory response. Conclusion: UHC1 shows anti-diabetic action by blocking CDK5-mediated PPARβ phosphorylation. Significance: UHC1 can be a novel therapeutic agent for use in type 2 diabetes and related metabolic disorders.
Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
ISSN
0021-9258

qrcode

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.