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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity

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Title
A novel non-agonist peroxisome proliferator-activated receptor γ (PPARγ) ligand UHC1 blocks PPARγ phosphorylation by cyclin-dependent kinase 5 (CDK5) and improves insulin sensitivity
Author
Choi, Sun-SilKim, Eun SunKoh, MinseobLee, Soo-JinLim, DonghyunYang, Yong RyoulJang, Hyun-JunSeo, Kyung-ahMin, Sang-HyunLee, In HeePark, Seung BumSuh, Pann-GhillChoi, Jang Hyun
Issue Date
2014-09
Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Citation
JOURNAL OF BIOLOGICAL CHEMISTRY, v.289, no.38, pp.26618 - 26629
Abstract
Background: PPARβ ligands can be used in numerous metabolic syndromes. Results: A novel non-agonist PPARβ ligand, UHC1 exhibited great beneficial effects on glucose metabolism and anti-inflammatory response. Conclusion: UHC1 shows anti-diabetic action by blocking CDK5-mediated PPARβ phosphorylation. Significance: UHC1 can be a novel therapeutic agent for use in type 2 diabetes and related metabolic disorders.
URI
https://scholarworks.unist.ac.kr/handle/201301/6901
URL
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84907203364
DOI
10.1074/jbc.M114.566794
ISSN
0021-9258
Appears in Collections:
BIO_Journal Papers
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