Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.number | 11 | - |
dc.citation.startPage | 1601 | - |
dc.citation.title | PHARMACEUTICALS | - |
dc.citation.volume | 16 | - |
dc.contributor.author | Kim, Jihye | - |
dc.contributor.author | Chang, Nakho | - |
dc.contributor.author | Kim, Yunki | - |
dc.contributor.author | Lee, Jaehyun | - |
dc.contributor.author | Oh, Daeseok | - |
dc.contributor.author | Choi, Jaeyoung | - |
dc.contributor.author | Kim, Onyou | - |
dc.contributor.author | Kim, Sujin | - |
dc.contributor.author | Choi, Myongho | - |
dc.contributor.author | Lee, Junyeob | - |
dc.contributor.author | Lee, Junghwa | - |
dc.contributor.author | Kim, Jungyul | - |
dc.contributor.author | Cho, Minji | - |
dc.contributor.author | Kim, Minsu | - |
dc.contributor.author | Lee, Kwanghwan | - |
dc.contributor.author | Hwang, Dukhyun | - |
dc.contributor.author | Sa, Jason K. | - |
dc.contributor.author | Park, Sungjin | - |
dc.contributor.author | Baek, Seungjae | - |
dc.contributor.author | Im, Daeseong | - |
dc.date.accessioned | 2024-01-19T12:05:25Z | - |
dc.date.available | 2024-01-19T12:05:25Z | - |
dc.date.created | 2024-01-15 | - |
dc.date.issued | 2023-11 | - |
dc.description.abstract | Non-alcoholic steatohepatitis (NASH) is a complex disease resulting from chronic liver injury associated with obesity, type 2 diabetes, and inflammation. Recently, the importance of developing multi-target drugs as a strategy to address complex diseases such as NASH has been growing; however, their manufacturing processes remain time- and cost-intensive and inefficient. To overcome these limitations, we developed UniStac, a novel enzyme-mediated conjugation platform for multi-specific drug development. UniStac demonstrated high conjugation yields, optimal thermal stabilities, and robust biological activities. We designed a tetra-specific compound, C-192, targeting glucagon-like peptide 1 (GLP-1), glucagon (GCG), fibroblast growth factor 21 (FGF21), and interleukin-1 receptor antagonist (IL-1RA) simultaneously for the treatment of NASH using UniStac. The biological activity and treatment efficacy of C-192 were confirmed both in vitro and in vivo using a methionine-choline-deficient (MCD) diet-induced mouse model. C-192 exhibited profound therapeutic efficacies compared to conventional drugs, including liraglutide and dulaglutide. C-192 significantly improved alanine transaminase levels, triglyceride accumulation, and the non-alcoholic fatty liver disease activity score. In this study, we demonstrated the feasibility of UniStac in creating multi-specific drugs and confirmed the therapeutic potential of C-192, a drug that integrates multiple mechanisms into a single molecule for the treatment of NASH. | - |
dc.identifier.bibliographicCitation | PHARMACEUTICALS, v.16, no.11, pp.1601 | - |
dc.identifier.doi | 10.3390/ph16111601 | - |
dc.identifier.issn | 1424-8247 | - |
dc.identifier.scopusid | 2-s2.0-85178381008 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/68065 | - |
dc.identifier.wosid | 001113573000001 | - |
dc.language | 영어 | - |
dc.publisher | MDPI | - |
dc.title | The Novel Tetra-Specific Drug C-192, Conjugated Using UniStac, Alleviates Non-Alcoholic Steatohepatitis in an MCD Diet-Induced Mouse Model | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal; Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | multi-specific | - |
dc.subject.keywordAuthor | conjugation | - |
dc.subject.keywordAuthor | platform | - |
dc.subject.keywordAuthor | complex disease | - |
dc.subject.keywordAuthor | NASH | - |
dc.subject.keywordAuthor | GLP-1 | - |
dc.subject.keywordAuthor | GCG | - |
dc.subject.keywordAuthor | FGF21 | - |
dc.subject.keywordAuthor | IL-1RA | - |
dc.subject.keywordAuthor | chronic inflammation | - |
dc.subject.keywordPlus | GCGR DUAL-AGONIST | - |
dc.subject.keywordPlus | UBIQUITIN | - |
dc.subject.keywordPlus | GLP-1R | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | POLYUBIQUITIN | - |
dc.subject.keywordPlus | LIPOTOXICITY | - |
dc.subject.keywordPlus | METHIONINE | - |
dc.subject.keywordPlus | CHEMISTRY | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | BIOLOGY | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.