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DC Field | Value | Language |
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dc.citation.number | 17 | - |
dc.citation.startPage | 2304862 | - |
dc.citation.title | SMALL | - |
dc.citation.volume | 20 | - |
dc.contributor.author | Byun, Min Ji | - |
dc.contributor.author | Seo, Hee Seung | - |
dc.contributor.author | Lee, Joonghak | - |
dc.contributor.author | Ban, Kitae | - |
dc.contributor.author | Oh, Serim | - |
dc.contributor.author | Lee, Yun Young | - |
dc.contributor.author | Lim, Jaesung | - |
dc.contributor.author | Lee, Na Kyeong | - |
dc.contributor.author | Wang, Chi-Pin James | - |
dc.contributor.author | Kim, Minjeong | - |
dc.contributor.author | Han, Jun-Hyeok | - |
dc.contributor.author | Park, Juwon | - |
dc.contributor.author | Paik, Taejong | - |
dc.contributor.author | Park, Hee Ho | - |
dc.contributor.author | Park, Tae-Eun | - |
dc.contributor.author | Park, Wooram | - |
dc.contributor.author | Kim, Se-Na | - |
dc.contributor.author | Park, Dae-Hwan | - |
dc.contributor.author | Park, Chun Gwon | - |
dc.date.accessioned | 2024-01-19T12:05:21Z | - |
dc.date.available | 2024-01-19T12:05:21Z | - |
dc.date.created | 2024-01-12 | - |
dc.date.issued | 2024-04 | - |
dc.description.abstract | Atopic dermatitis (AD) is a widespread, recurrent, and chronic inflammatory skin condition that imposes a major burden on patients. Conventional treatments, such as corticosteroids, are associated with various side effects, underscoring the need for innovative therapeutic approaches. In this study, the possibility of using indole-3-acetic acid-loaded layered double hydroxides (IAA-LDHs) is evaluated as a novel treatment for AD. IAA is an auxin-class plant hormone with antioxidant and anti-inflammatory effects. Following the synthesis of IAA-LDH nanohybrids, their ability to induce M2-like macrophage polarization in macrophages obtained from mouse bone marrow is assessed. The antioxidant activity of IAA-LDH is quantified by assessing the decrease in intracellular reactive oxygen species levels. The anti-inflammatory and anti-atopic characteristics of IAA-LDH are evaluated in a mouse model of AD by examining the cutaneous tissues, immunological organs, and cells. The findings suggest that IAA-LDH has great therapeutic potential as a candidate for AD treatment based on its in vitro and in vivo modulation of AD immunology, enhancement of macrophage polarization, and antioxidant activity. This inorganic drug delivery technology represents a promising new avenue for the development of safe and effective AD treatments. © 2023 Wiley-VCH GmbH. | - |
dc.identifier.bibliographicCitation | SMALL, v.20, no.17, pp.2304862 | - |
dc.identifier.doi | 10.1002/smll.202304862 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.scopusid | 2-s2.0-85178439039 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/68054 | - |
dc.identifier.wosid | 001112974200001 | - |
dc.language | 영어 | - |
dc.publisher | John Wiley and Sons Inc | - |
dc.title | Biofunctional Inorganic Layered Double Hydroxide Nanohybrid Enhances Immunotherapeutic Effect on Atopic Dermatitis Treatment | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary;Chemistry, Physical;Nanoscience & Nanotechnology;Materials Science, Multidisciplinary;Physics, Applied;Physics, Condensed Matter | - |
dc.relation.journalResearchArea | Chemistry;Science & Technology - Other Topics;Materials Science;Physics | - |
dc.type.docType | Article in press | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | atopic dermatitis | - |
dc.subject.keywordAuthor | immunosuppression | - |
dc.subject.keywordAuthor | layered double hydroxides | - |
dc.subject.keywordAuthor | macrophage polarization | - |
dc.subject.keywordAuthor | nanohybrid | - |
dc.subject.keywordPlus | IGE AUTOREACTIVITY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | BARRIER FUNCTION | - |
dc.subject.keywordPlus | MAST-CELLS | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | AUTOIMMUNITY | - |
dc.subject.keywordPlus | ANTIOXIDANTS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | ARGINASE | - |
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