Full metadata record
DC Field | Value | Language |
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dc.citation.startPage | 100189 | - |
dc.citation.title | Giant | - |
dc.citation.volume | 16 | - |
dc.contributor.author | Kim, Sangpil | - |
dc.contributor.author | Choi, Huyeon | - |
dc.contributor.author | Jin, Seongeon | - |
dc.contributor.author | Son, Sehee | - |
dc.contributor.author | Lee, Yeji | - |
dc.contributor.author | Kim, Kibeom | - |
dc.contributor.author | Ryu, Ja-Hyoung | - |
dc.date.accessioned | 2023-12-31T18:05:10Z | - |
dc.date.available | 2023-12-31T18:05:10Z | - |
dc.date.created | 2023-12-31 | - |
dc.date.issued | 2023-02 | - |
dc.description.abstract | Self-assembly generates three-dimensional architectures through the non-covalent interactions of building blocks of various sizes, ranging from nanometers to micrometers, and the assembled structures may have new functions that the building blocks do not have. Cell self-assembly has attracted considerable attention in cancer treatment because it can overcome the side effects of conventional chemotherapy and the low therapeutic effect on drug-resistant cells. In addition, the trigger in the building block reacts with the specific environment of the cancer, such as pH, ions, redox reactions, enzymes, or receptors, facilitating cancer-targeted therapy. However, the precise control of self-assembly for the construction of nanostructures is difficult in harsh intracellular environments. To overcome this challenge, various researchers have investigated intracellular self-assembly. In particular, the self-assembly in cellular organelles is of great interest. Compared with self-assembly in the cytoplasm of cells, organelle-targeting self-assembly has the advantage of being able to self-assemble without side effects under more stable conditions with a relatively low concentration of building blocks. In this mini-review, we discuss the latest research on self-assembly inside or near organelles for cancer treatment. | - |
dc.identifier.bibliographicCitation | Giant, v.16, pp.100189 | - |
dc.identifier.doi | 10.1016/j.giant.2023.100189 | - |
dc.identifier.issn | 2666-5425 | - |
dc.identifier.scopusid | 2-s2.0-85170660442 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/67399 | - |
dc.language | 영어 | - |
dc.publisher | Elsevier | - |
dc.title | Self-assembly inside cellular organelles: Aspects of functions and various strategies for cancer therapy | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Biological application | - |
dc.subject.keywordAuthor | Function | - |
dc.subject.keywordAuthor | Intracellular-self-assembly | - |
dc.subject.keywordAuthor | Nanostructure | - |
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