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Cho, Yoon-Kyoung
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dc.citation.endPage 56819 -
dc.citation.number 49 -
dc.citation.startPage 56807 -
dc.citation.volume 15 - Sunkara, Vijaya - Park, Juhee - Han, Jiyun - del Río, Jonathan Sabaté - Cho, Hyun-Ju - Oh, In-Jae - Cho, Yoon-Kyoung - 2023-12-14T17:10:18Z - 2023-12-14T17:10:18Z - 2023-12-13 - 2023-12 -
dc.description.abstract Extracellular vesicles (EVs) are emerging as crucial materials for precision theragnostic applications. However, current separation methods are time-consuming, costly, and not scalable and deliver limited yields or purity. Here, we present EV precipitation by ionic strength modulation (ExoPRISM), a simple, low-cost, user-friendly, and readily adaptable approach for separating EVs in high yields without compromising their biological functions. Adding an electrolyte solution to blood plasma in small increments generates the sequential precipitation of proteins and EVs, allowing for fractional separation of EVs using low-speed centrifugation. The coprecipitated electrolytes are easily washed away, and the entire EV separation and washing process takes less than an hour. This approach successfully separates EVs from a broad range of volumes and types of biological fluids, including culture medium, urine, plasma, and serum, showing promise as a robust tool for next-generation liquid biopsies and regenerative medicine. -
dc.identifier.bibliographicCitation ACS APPLIED MATERIALS & INTERFACES, v.15, no.49, pp.56807 - 56819 -
dc.identifier.doi 10.1021/acsami.3c13527 -
dc.identifier.issn 1944-8244 -
dc.identifier.scopusid 2-s2.0-85179606746 -
dc.identifier.uri -
dc.identifier.wosid 001142942000001 -
dc.language 영어 -
dc.publisher American Chemical Society -
dc.title Exosome Precipitation by Ionic Strength Modulation: ExoPRISM -
dc.type Article -
dc.description.isOpenAccess TRUE -
dc.relation.journalWebOfScienceCategory Science & Technology - Other Topics;Materials Science -
dc.relation.journalResearchArea Nanoscience & Nanotechnology;Materials Science, Multidisciplinary -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor electrolytes -
dc.subject.keywordAuthor EV isolation -
dc.subject.keywordAuthor EV precipitation -
dc.subject.keywordAuthor EV separation -
dc.subject.keywordAuthor exosomes -
dc.subject.keywordAuthor extracellular vesicles (EV) -
dc.subject.keywordPlus EXTRACELLULAR VESICLES -
dc.subject.keywordPlus HOFMEISTER SERIES -
dc.subject.keywordPlus SALTING-OUT -
dc.subject.keywordPlus TUMOR -


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