There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 56819 | - |
dc.citation.number | 49 | - |
dc.citation.startPage | 56807 | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 15 | - |
dc.contributor.author | Sunkara, Vijaya | - |
dc.contributor.author | Park, Juhee | - |
dc.contributor.author | Han, Jiyun | - |
dc.contributor.author | del Río, Jonathan Sabaté | - |
dc.contributor.author | Cho, Hyun-Ju | - |
dc.contributor.author | Oh, In-Jae | - |
dc.contributor.author | Cho, Yoon-Kyoung | - |
dc.date.accessioned | 2023-12-14T17:10:18Z | - |
dc.date.available | 2023-12-14T17:10:18Z | - |
dc.date.created | 2023-12-13 | - |
dc.date.issued | 2023-12 | - |
dc.description.abstract | Extracellular vesicles (EVs) are emerging as crucial materials for precision theragnostic applications. However, current separation methods are time-consuming, costly, and not scalable and deliver limited yields or purity. Here, we present EV precipitation by ionic strength modulation (ExoPRISM), a simple, low-cost, user-friendly, and readily adaptable approach for separating EVs in high yields without compromising their biological functions. Adding an electrolyte solution to blood plasma in small increments generates the sequential precipitation of proteins and EVs, allowing for fractional separation of EVs using low-speed centrifugation. The coprecipitated electrolytes are easily washed away, and the entire EV separation and washing process takes less than an hour. This approach successfully separates EVs from a broad range of volumes and types of biological fluids, including culture medium, urine, plasma, and serum, showing promise as a robust tool for next-generation liquid biopsies and regenerative medicine. | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.15, no.49, pp.56807 - 56819 | - |
dc.identifier.doi | 10.1021/acsami.3c13527 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.scopusid | 2-s2.0-85179606746 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/66415 | - |
dc.identifier.wosid | 001142942000001 | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Exosome Precipitation by Ionic Strength Modulation: ExoPRISM | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Science & Technology - Other Topics;Materials Science | - |
dc.relation.journalResearchArea | Nanoscience & Nanotechnology;Materials Science, Multidisciplinary | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | electrolytes | - |
dc.subject.keywordAuthor | EV isolation | - |
dc.subject.keywordAuthor | EV precipitation | - |
dc.subject.keywordAuthor | EV separation | - |
dc.subject.keywordAuthor | exosomes | - |
dc.subject.keywordAuthor | extracellular vesicles (EV) | - |
dc.subject.keywordPlus | EXTRACELLULAR VESICLES | - |
dc.subject.keywordPlus | HOFMEISTER SERIES | - |
dc.subject.keywordPlus | SALTING-OUT | - |
dc.subject.keywordPlus | TUMOR | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.