There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 781 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 766 | - |
dc.citation.title | TRENDS IN IMMUNOLOGY | - |
dc.citation.volume | 44 | - |
dc.contributor.author | Tripathi, Shubham | - |
dc.contributor.author | Tsang, John S. | - |
dc.contributor.author | Park, Kyemyung | - |
dc.date.accessioned | 2023-12-21T11:42:13Z | - |
dc.date.available | 2023-12-21T11:42:13Z | - |
dc.date.created | 2023-11-16 | - |
dc.date.issued | 2023-10 | - |
dc.description.abstract | Regulatory T (Treg) cells play vital roles in immune homeostasis and response, including discrimination between self-and non-self-antigens, containment of immunopathology, and inflammation resolution. These diverse functions are orchestrated by cellular circuits involving Tregs and other cell types across space and time. Despite dramatic progress in our understanding of Treg biology, a quantitative framework capturing how Treg-containing circuits give rise to these diverse functions is lacking. Here, we propose that different facets of Treg func-tion can be interpreted as distinct operating regimes of the same underlying circuit. We discuss how a systems immunology approach, involving quantitative experiments, computational modeling, and machine learning, can advance our understanding of Treg function, and help identify general operating and design principles underlying immune regulation. | - |
dc.identifier.bibliographicCitation | TRENDS IN IMMUNOLOGY, v.44, no.10, pp.766 - 781 | - |
dc.identifier.doi | 10.1016/j.it.2023.08.007 | - |
dc.identifier.issn | 1471-4906 | - |
dc.identifier.scopusid | 2-s2.0-85170209472 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/66205 | - |
dc.identifier.wosid | 001088958600001 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Systems immunology of regulatory T cells: can one circuit explain it all? | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.type.docType | Review | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | TGF-BETA | - |
dc.subject.keywordPlus | SELF | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | PRECURSOR FREQUENCY | - |
dc.subject.keywordPlus | INDUCED EXPANSION | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | IL-2 RECEPTOR | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.