Full metadata record
DC Field | Value | Language |
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dc.citation.number | 1 | - |
dc.citation.title | BIOMATERIALS RESEARCH | - |
dc.citation.volume | 27 | - |
dc.contributor.author | Diep, Yen N. | - |
dc.contributor.author | Park, Hee Jung | - |
dc.contributor.author | Kwon, Joon-Ho | - |
dc.contributor.author | Tran, Minh | - |
dc.contributor.author | Ko, Hae Young | - |
dc.contributor.author | Jo, Hanhee | - |
dc.contributor.author | Kim, Jisu | - |
dc.contributor.author | Chung, Jee-In | - |
dc.contributor.author | Kim, Tai Young | - |
dc.contributor.author | Kim, Dongwoo | - |
dc.contributor.author | Chang, Jong Hee | - |
dc.contributor.author | Kang, You Jung | - |
dc.contributor.author | Lee, C. Justin | - |
dc.contributor.author | Yun, Mijin | - |
dc.contributor.author | Cho, Hansang | - |
dc.date.accessioned | 2023-12-21T11:50:25Z | - |
dc.date.available | 2023-12-21T11:50:25Z | - |
dc.date.created | 2023-09-01 | - |
dc.date.issued | 2023-07 | - |
dc.description.abstract | Background Glial scar formation is a reactive glial response confining injured regions in a central nervous system. However, it remains challenging to identify key factors formulating glial scar in response to glioblastoma (GBM) due to complex glia-GBM crosstalk. Methods Here, we constructed an astrocytic scar enclosing GBM in a human assembloid and a mouse xenograft model. GBM spheroids were preformed and then co-cultured with microglia and astrocytes in 3D Matrigel. For the xenograft model, U87-MG cells were subcutaneously injected to the Balb/C nude female mice. Results Additional glutamate was released from GBM-microglia assembloid by 3.2-folds compared to GBM alone. The glutamate upregulated astrocytic monoamine oxidase-B (MAO-B) activity and chondroitin sulfate proteoglycans (CSPGs) deposition, forming the astrocytic scar and restricting GBM growth. Attenuating scar formation by the glutamate-MAO-B inhibition increased drug penetration into GBM assembloid, while reducing GBM confinement. Conclusions Taken together, our study suggests that astrocytic scar could be a critical modulator in GBM therapeutics. | - |
dc.identifier.bibliographicCitation | BIOMATERIALS RESEARCH, v.27, no.1 | - |
dc.identifier.doi | 10.1186/s40824-023-00408-4 | - |
dc.identifier.issn | 1226-4601 | - |
dc.identifier.scopusid | 2-s2.0-85165422194 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/65318 | - |
dc.identifier.wosid | 001033494300001 | - |
dc.language | 영어 | - |
dc.publisher | SPRINGERNATURE | - |
dc.title | Astrocytic scar restricting glioblastoma via glutamate-MAO-B activity in glioblastoma-microglia assembloid | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical; Materials Science, Biomaterials | - |
dc.relation.journalResearchArea | Engineering; Materials Science | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Glial scar formation | - |
dc.subject.keywordAuthor | MAO-B | - |
dc.subject.keywordAuthor | Glutamate | - |
dc.subject.keywordAuthor | Glioblastoma | - |
dc.subject.keywordAuthor | Microglia | - |
dc.subject.keywordAuthor | Assembloid | - |
dc.subject.keywordPlus | MONOAMINE-OXIDASE-B | - |
dc.subject.keywordPlus | REACTIVE ASTROCYTES | - |
dc.subject.keywordPlus | MODELS | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | GLIOMA | - |
dc.subject.keywordPlus | CELLS | - |
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