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DC Field | Value | Language |
---|---|---|
dc.citation.number | 16 | - |
dc.citation.startPage | 2215166 | - |
dc.citation.title | ADVANCED FUNCTIONAL MATERIALS | - |
dc.citation.volume | 33 | - |
dc.contributor.author | Kim, Seong Yeol | - |
dc.contributor.author | Thangam, Ramar | - |
dc.contributor.author | Kang, Nayeon | - |
dc.contributor.author | Hong, Hyunsik | - |
dc.contributor.author | Kim, Chowon | - |
dc.contributor.author | Lee, Sungkyu | - |
dc.contributor.author | Son, Subin | - |
dc.contributor.author | Lee, Hyun-Jeong | - |
dc.contributor.author | Tag, Kyong-Ryol | - |
dc.contributor.author | Min, Sunhong | - |
dc.contributor.author | Jeong, Daun | - |
dc.contributor.author | Hwang, Jangsun | - |
dc.contributor.author | Kim, Kanghyeon | - |
dc.contributor.author | Kim, Dahee | - |
dc.contributor.author | Kim, Yuri | - |
dc.contributor.author | Joo, Jinmyoung | - |
dc.contributor.author | Kim, Bong Hoon | - |
dc.contributor.author | Zhu, Yangzhi | - |
dc.contributor.author | Park, Sung-Gyu | - |
dc.contributor.author | Song, Hyun-Cheol | - |
dc.contributor.author | Sun, Wujin | - |
dc.contributor.author | Ahn, Jae-Pyoung | - |
dc.contributor.author | Jang, Woo Young | - |
dc.contributor.author | Paulmurugan, Ramasamy | - |
dc.contributor.author | Kim, Hong-Kyu | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.contributor.author | Kang, Heemin | - |
dc.date.accessioned | 2023-12-21T12:41:06Z | - |
dc.date.available | 2023-12-21T12:41:06Z | - |
dc.date.created | 2023-08-15 | - |
dc.date.issued | 2023-04 | - |
dc.description.abstract | Extracellular matrix (ECM) proteins containing cell-attachable Arg-Gly-Asp (RGD) sequences exhibit variable bridging and non-bridging in fibronectin-collagen and laminin-collagen complexes that can regulate inflammation, tissue repair, and wound healing. In this study, linking molecule-mediated conjugation of 1D magnetic nanocylinders (MNCs) to material surfaces pre-decorated with gold nanospheres (GNSs) is performed, thereby yielding RGD-coated MNCs (RGD-MNCs) over RGD-coated GNSs (RGD-GNSs) in a non-bridging state. The RGD-MNCs are drawn closer to the RGD-GNSs via magnetic field-mediated compression of the linking molecules to establish the bridging between them. Relative proportion of the RGD-MNCs to the RGD-GNSs is optimized to yield effective remote stimulation of integrin binding to variably bridged RGDs similar to that of invariably bridged RGDs used as a control group. Remote manipulation of the RGD bridging facilitates the attachment structure assembly of macrophages that leads to pro-healing/anti-inflammatory phenotype acquisition. In contrast, the non-bridged RGDs inhibited macrophage attachment that acquired pro-inflammatory phenotypes. The use of various nanomaterials in constructing heterogeneous RGD-coated materials can further offer various modes in remote switching of RGD bridging and non-bridging to understand dynamic integrin-mediated modulation of macrophages that regulate immunomodulatory responses, such as foreign body responses, tissue repair, and wound healing. | - |
dc.identifier.bibliographicCitation | ADVANCED FUNCTIONAL MATERIALS, v.33, no.16, pp.2215166 | - |
dc.identifier.doi | 10.1002/adfm.202215166 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.scopusid | 2-s2.0-85147518352 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/65207 | - |
dc.identifier.wosid | 000929290700001 | - |
dc.language | 영어 | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | Modulation of Macrophages by In Situ Ligand Bridging | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | in situ bridging | - |
dc.subject.keywordAuthor | ligand bridging | - |
dc.subject.keywordAuthor | macrophage adhesions | - |
dc.subject.keywordAuthor | macrophage polarization | - |
dc.subject.keywordAuthor | remote controls | - |
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