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Jeong, Hoon Eui
Multiscale Biomimetics and Manufacturing Lab.
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dc.citation.number 29 -
dc.citation.startPage 2307114 -
dc.citation.title ADVANCED HEALTHCARE MATERIALS -
dc.citation.volume 12 -
dc.contributor.author Saleh, Rabi Ibrahim -
dc.contributor.author Kim, Suntae -
dc.contributor.author Lee, Sang-Hyeon -
dc.contributor.author Kwon, Hyukjoo -
dc.contributor.author Jeong, Hoon Eui -
dc.contributor.author Cha, Chaenyung -
dc.date.accessioned 2023-12-21T11:51:52Z -
dc.date.available 2023-12-21T11:51:52Z -
dc.date.created 2023-08-07 -
dc.date.issued 2023-11 -
dc.description.abstract As point-of-care testing (POCT) is becoming the new paradigm of medical diagnostics, there is a growing need to develop reliable POCT devices that can be conveniently operated in a minimally invasive manner. However, the clinical potential of POCT diagnostics is yet to be realized, mainly due to the limited and inconsistent amount of collected samples on these devices, undermining their accuracy. This study proposes a new biosensing platform modified with a functional polysuccinimide (PSI)-silica nanoparticle (SNP) composite system that can substantially increase the protein conjugation efficiency by modulating physicochemical interaction with proteins by several hundred percent from an unmodified device. The efficacy of this PSI-SNP system is further validated by applying it on the surface of a microneedle array (MN), which has emerged as a promising POCT device capable of accessing interstitial fluid through minimal penetration of the skin. This PSI-SNP MN is demonstrated to detect a wide array of proteins with high sensitivity on par with conventional whole serum analysis, validated by in vivo animal testing, effectively displaying broad applicability in biomedical engineering. -
dc.identifier.bibliographicCitation ADVANCED HEALTHCARE MATERIALS, v.12, no.29, pp.2307114 -
dc.identifier.doi 10.1002/adhm.202301774 -
dc.identifier.issn 2192-2640 -
dc.identifier.scopusid 2-s2.0-85165451392 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/65179 -
dc.identifier.wosid 001033750600001 -
dc.language 영어 -
dc.publisher WILEY -
dc.title Manipulating Physicochemical Properties of Biosensor Platform with Polysuccinimide-Silica Nanocomposite for Enhanced Protein Detection -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Engineering, Biomedical; Nanoscience & Nanotechnology; Materials Science, Biomaterials -
dc.relation.journalResearchArea Engineering; Science & Technology - Other Topics; Materials Science -
dc.type.docType Article; Early Access -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor microneedles -
dc.subject.keywordAuthor point-of-care testing -
dc.subject.keywordAuthor polysuccinimide -
dc.subject.keywordAuthor protein detections -
dc.subject.keywordAuthor silica nanoparticles -
dc.subject.keywordPlus HYDROPHOBICITY -
dc.subject.keywordPlus NANOPARTICLES -
dc.subject.keywordPlus GEL -

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