Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1317 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1309 | - |
dc.citation.title | CHEM | - |
dc.citation.volume | 9 | - |
dc.contributor.author | Choe, Jisu | - |
dc.contributor.author | Kim, Soo Jin | - |
dc.contributor.author | Kim, Jun-Hyeong | - |
dc.contributor.author | Baik, Mu-Hyun | - |
dc.contributor.author | Lee, Junyeop | - |
dc.contributor.author | Cho, Jaeheung | - |
dc.date.accessioned | 2023-12-21T12:38:44Z | - |
dc.date.available | 2023-12-21T12:38:44Z | - |
dc.date.created | 2023-06-27 | - |
dc.date.issued | 2023-05 | - |
dc.description.abstract | Retinal vascular occlusion (RVO) is a common cause of visual impair-ment. Although several approaches, including vasodilators, have been explored to treat retinal vascular occlusion, there is no proper method to treat this obstruction today. We report a strategy that aims to pierce clogged blood vessels with a spatiotemporally controllable nitric oxide transporter, [Fe(TBDAP)(NO)(H2O)]2+ (1), which was synthesized and precisely characterized by various phys-icochemical methods, including X-ray crystallography. In the animal model, normal retinal blood vessels were confirmed to be dilated by the photoresponsive iron-nitrosyl complex. Furthermore, occluded retinal blood vessels were effectively reperfused after the immedi-ate delivery of nitric oxide using light in animal disease models. These studies suggest an unprecedentedly selective and control-lable treatment option for acute vascular occlusive diseases, including cardiovascular and cerebrovascular diseases. | - |
dc.identifier.bibliographicCitation | CHEM, v.9, no.5, pp.1309 - 1317 | - |
dc.identifier.doi | 10.1016/j.chempr.2023.02.013 | - |
dc.identifier.issn | 2451-9294 | - |
dc.identifier.scopusid | 2-s2.0-85151517360 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/64716 | - |
dc.identifier.wosid | 001001479100001 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Photodynamic treatment of acute vascular occlusion by using an iron-nitrosyl complex | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | RETINAL ARTERY-OCCLUSION | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | ELECTRONIC-STRUCTURE | - |
dc.subject.keywordPlus | THEORETICAL DESCRIPTION | - |
dc.subject.keywordPlus | NO | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MODELS | - |
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