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dc.citation.number 3 -
dc.citation.startPage 119428 -
dc.citation.volume 1870 - Sharma, Nirmali - Mishra, Pratyush Kumar - Yoo, Chang-Mo - Jung, Minkyo - Mun, Ji Young - Rhee, Hyun Woo - 2023-12-21T12:45:25Z - 2023-12-21T12:45:25Z - 2023-06-13 - 2023-03 -
dc.description.abstract Peroxidase is a heme-containing enzyme that reduces hydrogen peroxide to water by extracting electron(s) from aromatic compounds via a sequential turnover reaction. This reaction can generate various aromatic radicals in the form of short-lived "spray" molecules. These can be either covalently attached to proximal proteins or polymerized via radical-radical coupling. Recent studies have shown that these peroxidase-generated radicals can be utilized as effective tools for spatial research in biological systems, including imaging studies aimed at the spatial localization of proteins using electron microscopy, spatial proteome mapping, and spatial sensing of metabolites (e.g., heme and hydrogen peroxide). This review may facilitate the wider utilization of these peroxidase-based methods for spatial discovery in cellular biology. -
dc.identifier.bibliographicCitation BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, v.1870, no.3, pp.119428 -
dc.identifier.doi 10.1016/j.bbamcr.2022.119428 -
dc.identifier.issn 0167-4889 -
dc.identifier.scopusid 2-s2.0-85146652626 -
dc.identifier.uri -
dc.identifier.wosid 000992261300001 -
dc.language 영어 -
dc.publisher ELSEVIER -
dc.title A multifunctional peroxidase-based reaction for imaging, sensing and networking of spatial biology -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Biochemistry & Molecular Biology; Cell Biology -
dc.relation.journalResearchArea Biochemistry & Molecular Biology; Cell Biology -
dc.type.docType Review -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor Peroxidase -
dc.subject.keywordAuthor Electron microscope -
dc.subject.keywordAuthor Molecular map -
dc.subject.keywordAuthor Sensor -
dc.subject.keywordAuthor Spatial polymerization -
dc.subject.keywordPlus HORSERADISH-PEROXIDASE -
dc.subject.keywordPlus ELECTRON-MICROSCOPY -
dc.subject.keywordPlus ENDOCYTIC TRAFFICKING -
dc.subject.keywordPlus PROTEIN INTERACTIONS -
dc.subject.keywordPlus HEME TRAFFICKING -
dc.subject.keywordPlus LIVING CELLS -
dc.subject.keywordPlus APEX -
dc.subject.keywordPlus LOCALIZATION -
dc.subject.keywordPlus REPORTER -
dc.subject.keywordPlus TISSUES -


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