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DC Field | Value | Language |
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dc.citation.startPage | 101873 | - |
dc.citation.title | MOLECULAR AND CELLULAR PROBES | - |
dc.citation.volume | 66 | - |
dc.contributor.author | Kim, Yeo Jin | - |
dc.contributor.author | Jeon, Hahyeon | - |
dc.contributor.author | Jeon, Sungwon | - |
dc.contributor.author | Lee, Sung-Hun | - |
dc.contributor.author | Kim, Changjae | - |
dc.contributor.author | Ahn, Ji-Hye | - |
dc.contributor.author | Um, Hyojin | - |
dc.contributor.author | Woo, Yeong Ju | - |
dc.contributor.author | Jeong, Seong-ho | - |
dc.contributor.author | Kim, Yeonkyung | - |
dc.contributor.author | Park, Ha-Young | - |
dc.contributor.author | Oh, Hyung-Joo | - |
dc.contributor.author | Cho, Hyun-Ju | - |
dc.contributor.author | Bae, Jin-Han | - |
dc.contributor.author | Kim, Ji-Hoon | - |
dc.contributor.author | An, Seolbin | - |
dc.contributor.author | Kang, Sung-Bong | - |
dc.contributor.author | Jho, Sungwoong | - |
dc.contributor.author | Biro, Orsolya | - |
dc.contributor.author | Kis, David | - |
dc.contributor.author | Kim, Byung Chul | - |
dc.contributor.author | Kim, Yumi | - |
dc.contributor.author | Kim, Jae Hyun | - |
dc.contributor.author | Kim, Byoung-Chul | - |
dc.contributor.author | Bhak, Jong | - |
dc.contributor.author | Oh, In-Jae | - |
dc.date.accessioned | 2023-12-21T13:11:55Z | - |
dc.date.available | 2023-12-21T13:11:55Z | - |
dc.date.created | 2023-03-03 | - |
dc.date.issued | 2022-12 | - |
dc.description.abstract | Early detection is critical for minimizing mortality from cancer. Plasma cell-free DNA (cfDNA) contains the signatures of tumor DNA, allowing us to quantify the signature and diagnose early-stage tumors. Here, we report a novel tumor fragment quantification method, TOF (Tumor Originated Fragment) for the diagnosis of lung cancer by quantifying and analyzing both the plasma cfDNA methylation patterns and fragmentomic signatures. TOF utilizes the amount of ctDNA predicted from the methylation density information of each cfDNA read mapped on 6243 lung-tumor-specific CpG markers. The 6243 tumor-specific markers were derived from lung tumor tissues by comparing them with corresponding normal tissues and healthy blood from public methylation data. TOF also utilizes two cfDNA fragmentomic signatures: 1) the short fragment ratio, and 2) the 5 ' end-motif profile. We used 298 plasma samples to analyze cfDNA signatures using enzymatic methyl-sequencing data from 201 lung cancer patients and 97 healthy controls. The TOF score showed 0.98 of the area under the curve in correctly classifying lung cancer from normal samples. The TOF score resolution was high enough to clearly differentiate even the early-stage non-small cell lung cancer patients from the healthy controls. The same was true for small cell lung cancer patients. | - |
dc.identifier.bibliographicCitation | MOLECULAR AND CELLULAR PROBES, v.66, pp.101873 | - |
dc.identifier.doi | 10.1016/j.mcp.2022.101873 | - |
dc.identifier.issn | 0890-8508 | - |
dc.identifier.scopusid | 2-s2.0-85142290362 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/62289 | - |
dc.identifier.wosid | 000913192600001 | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | - |
dc.title | A method for early diagnosis of lung cancer from tumor originated DNA fragments using plasma cfDNA methylome and fragmentome profiles | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemical Research Methods; Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | cfDNA fragmentome | - |
dc.subject.keywordAuthor | cfDNA methylome | - |
dc.subject.keywordAuthor | Lung cancer | - |
dc.subject.keywordAuthor | Liquid biopsy | - |
dc.subject.keywordAuthor | Early cancer diagnosis | - |
dc.subject.keywordAuthor | Tumor originated fragments (TOF) score | - |
dc.subject.keywordPlus | MORTALITY | - |
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