Full metadata record
DC Field | Value | Language |
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dc.citation.number | 4 | - |
dc.citation.startPage | 195 | - |
dc.citation.title | CELLULAR AND MOLECULAR LIFE SCIENCES | - |
dc.citation.volume | 79 | - |
dc.contributor.author | Ratti, Stefano | - |
dc.contributor.author | Marvi, Maria Vittoria | - |
dc.contributor.author | Mongiorgi, Sara | - |
dc.contributor.author | Obeng, Eric Owusu | - |
dc.contributor.author | Rusciano, Isabella | - |
dc.contributor.author | Ramazzotti, Giulia | - |
dc.contributor.author | Morandi, Luca | - |
dc.contributor.author | Asioli, Sofia | - |
dc.contributor.author | Zoli, Matteo | - |
dc.contributor.author | Mazzatenta, Diego | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Manzoli, Lucia | - |
dc.contributor.author | Cocco, Lucio | - |
dc.date.accessioned | 2023-12-21T14:17:59Z | - |
dc.date.available | 2023-12-21T14:17:59Z | - |
dc.date.created | 2022-04-04 | - |
dc.date.issued | 2022-04 | - |
dc.description.abstract | Glioblastoma represents the most lethal brain tumor in adults. Several studies have shown the key role of phospholipase C beta 1 (PLC beta 1) in the regulation of many mechanisms within the central nervous system suggesting PLC beta 1 as a novel signature gene in the molecular classification of high-grade gliomas. This study aims to determine the pathological impact of PLC beta 1 in glioblastoma, confirming that PLC beta 1 gene expression correlates with glioma's grade, and it is lower in 50 glioblastoma samples compared to 20 healthy individuals. PLC beta 1 silencing in cell lines and primary astrocytes, leads to increased cell migration and invasion, with the increment of mesenchymal transcription factors and markers, as Slug and N-Cadherin and metalloproteinases. Cell proliferation, through increased Ki-67 expression, and the main survival pathways, as beta-catenin, ERK1/2 and Stat3 pathways, are also affected by PLC beta 1 silencing. These data suggest a potential role of PLC beta 1 in maintaining a normal or less aggressive glioma phenotype. | - |
dc.identifier.bibliographicCitation | CELLULAR AND MOLECULAR LIFE SCIENCES, v.79, no.4, pp.195 | - |
dc.identifier.doi | 10.1007/s00018-022-04198-1 | - |
dc.identifier.issn | 1420-682X | - |
dc.identifier.scopusid | 2-s2.0-85126690994 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/61153 | - |
dc.identifier.url | https://link.springer.com/article/10.1007/s00018-022-04198-1 | - |
dc.identifier.wosid | 000770616700001 | - |
dc.language | 영어 | - |
dc.publisher | SPRINGER BASEL AG | - |
dc.title | Impact of phospholipase C beta 1 in glioblastoma: a study on the main mechanisms of tumor aggressiveness | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Cell Biology | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Phosphoinositides | - |
dc.subject.keywordAuthor | Brain cancer | - |
dc.subject.keywordAuthor | Glioma | - |
dc.subject.keywordAuthor | Patients | - |
dc.subject.keywordAuthor | Cellular signaling | - |
dc.subject.keywordAuthor | Biomarkers | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | MULTIFORME | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
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