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Park, Tae-Eun
Micro Tissue Engineering & Nanomedicine Lab.
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dc.citation.startPage 115057 -
dc.citation.volume 224 - Sabaté del Río, Jonathan - Ro, Jooyoung - Yoon, Heejeong - Park, Tae-Eun - Cho, Yoon-Kyoung - 2023-12-21T12:50:16Z - 2023-12-21T12:50:16Z - 2023-01-05 - 2023-03 -
dc.description.abstract Organs-on-chips (OoCs) are biomimetic in vitro systems based on microfluidic cell cultures that recapitulate the in vivo physicochemical microenvironments and the physiologies and key functional units of specific human organs. These systems are versatile and can be customized to investigate organ-specific physiology, pathology, or pharmacology. They are more physiologically relevant than traditional two-dimensional cultures, can potentially replace the animal models or reduce the use of these models, and represent a unique opportunity for the development of personalized medicine when combined with human induced pluripotent stem cells. Continuous monitoring of important quality parameters of OoCs via a label-free, non-destructive, reliable, high-throughput, and multiplex method is critical for assessing the conditions of these systems and generating relevant analytical data; moreover, elaboration of quality predictive models is required for clinical trials of OoCs. Presently, these analytical data are obtained by manual or automatic sampling and analyzed using single-point, off-chip traditional methods. In this review, we describe recent efforts to integrate biosensing technologies into OoCs for monitoring the physiologies, functions, and physicochemical microenvironments of OoCs. Furthermore, we present potential alternative solutions to current challenges and future directions for the application of artificial intelligence in the development of OoCs and cyber-physical systems. These “smart” OoCs can learn and make autonomous decisions for process optimization, self-regulation, and data analysis. -
dc.identifier.bibliographicCitation BIOSENSORS & BIOELECTRONICS, v.224, pp.115057 -
dc.identifier.doi 10.1016/j.bios.2022.115057 -
dc.identifier.issn 0956-5663 -
dc.identifier.scopusid 2-s2.0-85146049382 -
dc.identifier.uri -
dc.identifier.wosid 000925116700001 -
dc.language 영어 -
dc.publisher Pergamon Press Ltd. -
dc.title Integrated technologies for continuous monitoring of organs-on-chips: Current challenges and potential solutions -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Biophysics;Biotechnology & Applied Microbiology;Chemistry, Analytical;Electrochemistry;Nanoscience & Nanotechnology -
dc.relation.journalResearchArea Biophysics;Biotechnology & Applied Microbiology;Chemistry;Electrochemistry;Science & Technology - Other Topics -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordAuthor Biosensors -
dc.subject.keywordAuthor Organ-on-a-chip -
dc.subject.keywordAuthor Microphysiological systems -
dc.subject.keywordAuthor Tissue chips -
dc.subject.keywordAuthor In vitro models -
dc.subject.keywordPlus A-CHIP -
dc.subject.keywordPlus ELECTRICAL-RESISTANCE -
dc.subject.keywordPlus MULTIELECTRODE ARRAY -
dc.subject.keywordPlus MINI-MICROSCOPE -
dc.subject.keywordPlus DNA BIOSENSORS -
dc.subject.keywordPlus TISSUE MODELS -
dc.subject.keywordPlus IN-VITRO -
dc.subject.keywordPlus PLATFORM -
dc.subject.keywordPlus CULTURE -
dc.subject.keywordPlus CELLS -


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