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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1582 | - |
dc.citation.number | 17 | - |
dc.citation.startPage | 1578 | - |
dc.citation.title | CURRENT BIOLOGY | - |
dc.citation.volume | 15 | - |
dc.contributor.author | Menzies, FM | - |
dc.contributor.author | Yenisetti, SC | - |
dc.contributor.author | Min, Kyung-Tai | - |
dc.date.accessioned | 2023-12-22T10:13:46Z | - |
dc.date.available | 2023-12-22T10:13:46Z | - |
dc.date.created | 2014-09-15 | - |
dc.date.issued | 2005-09 | - |
dc.description.abstract | The loss of dopaminergic neurons in the substantia nigra is the pathological hallmark of Parkinson's disease (PD). While the etiology of sporadic PD remains elusive, an inherited form of early-onset familial PD is linked to mutations of DJ-1 [1]. To understand the biological function of DJ-1 and its relevance to the pathogenesis of PD, we investigated the function of DJ-1 using Drosophila. Drosophila possesses two homologs of human DJ-1: DJ-1 alpha and DJ-1 beta. We found that DJ-1a is expressed predominantly in the testis, while DJ-1 beta is ubiquitously present in most tissues, resembling the expression pattern of human DJ-1. Loss-of-function DJ-1 beta mutants demonstrated an extended survival of dopaminergic neurons and resistance to paraquat stress, but showed acute sensitivity to hydrogen peroxide treatment. We showed a compensatory upregulation of DJ-1 alpha expression in the brain of the DJ-1 beta mutant and demonstrated that overexpression of DJ-1 alpha in dopaminergic neurons is sufficient to confer protection against paraquat insult. These results suggest that Drosophila homologs of DJ-1 play critical roles in the survival of dopaminergic neurons and response to oxidative stress. | - |
dc.identifier.bibliographicCitation | CURRENT BIOLOGY, v.15, no.17, pp.1578 - 1582 | - |
dc.identifier.doi | 10.1016/j.cub.2005.07.036 | - |
dc.identifier.issn | 0960-9822 | - |
dc.identifier.scopusid | 2-s2.0-24044506249 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/6058 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=24044506249 | - |
dc.identifier.wosid | 000231865700029 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | MODEL | - |
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