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Min, Kyung-Tai
Molecular & Cellular Neurobiology Lab(Min Lab)
Research Interests
  • adult neurogenesis; axon development; axon regeneration; protein stability; protein synthesis; Down syndrome; Alzheimer's disease;
  • learning and memory; mitochondria dynamics

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Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function

DC Field Value Language
dc.contributor.author Chang, KT ko
dc.contributor.author Min, Kyung-Tai ko
dc.date.available 2014-09-16T06:57:19Z -
dc.date.created 2014-09-15 ko
dc.date.issued 2005-11 -
dc.identifier.citation NATURE NEUROSCIENCE, v.8, no.11, pp.1577 - 1585 ko
dc.identifier.issn 1097-6256 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/6054 -
dc.identifier.uri http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=27644557511 ko
dc.description.abstract Mitochondrial dysfunction has emerged as a common theme that underlies numerous neurological disorders, including Down syndrome. Down syndrome cultures and tissues show mitochondrial damage such as impaired mitochondrial enzyme activities, defective mitochondrial DNA repairs and accumulation of toxic free radicals, but the cause of mitochondrial dysfunction remains elusive. Here we demonstrate that the Drosophila melanogaster homolog of human Down syndrome critical region gene 1 (DSCR1), nebula (also known as sarah, sra), has a crucial role in the maintenance of mitochondrial function and integrity. We report that nebula protein is located in the mitochondria. An alteration in the abundance of nebula affects mitochondrial enzyme activities, mitochondrial DNA content, and the number and size of mitochondria. Furthermore, nebula interacts with the ADP/ATP translocator and influences its activity. These results identify nebula/DSCR1 as a regulator of mitochondrial function and integrity and further suggest that an increased level of DSCR1 may contribute to the mitochondrial dysfunction seen in Down syndrome. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher NATURE PUBLISHING GROUP ko
dc.subject ADENINE-NUCLEOTIDE TRANSLOCATOR ko
dc.subject OXIDATIVE STRESS ko
dc.subject ALZHEIMERS-DISEASE ko
dc.subject SUPEROXIDE PRODUCTION ko
dc.subject INHIBITS CALCINEURIN ko
dc.subject DSCR1 ADAPT78 ko
dc.subject MOUSE MODELS ko
dc.subject PROTEIN ko
dc.subject GENE ko
dc.subject PHOSPHORYLATION ko
dc.title Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-27644557511 ko
dc.identifier.wosid 000232966600033 ko
dc.type.rims ART ko
dc.description.wostc 38 *
dc.description.scopustc 38 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-09-15 *
dc.identifier.doi 10.1038/nn1564 ko
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