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DC Field | Value | Language |
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dc.citation.number | 1 | - |
dc.citation.startPage | 10550 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 12 | - |
dc.contributor.author | Sangjan, Amornrat | - |
dc.contributor.author | Boonsith, Suthida | - |
dc.contributor.author | Sansanaphongpricha, Kanokwan | - |
dc.contributor.author | Thinbanmai, Tapanee | - |
dc.contributor.author | Ratchahat, Sakhon | - |
dc.contributor.author | Laosiripojana, Navadol | - |
dc.contributor.author | Wu, Kevin C. W. | - |
dc.contributor.author | Shin, Hyeon Suk | - |
dc.contributor.author | Sakdaronnarong, Chularat | - |
dc.date.accessioned | 2023-12-21T14:07:56Z | - |
dc.date.available | 2023-12-21T14:07:56Z | - |
dc.date.created | 2022-07-14 | - |
dc.date.issued | 2022-06 | - |
dc.description.abstract | Carbon dots (CDs) are categorized as an emerging class of zero-dimension nanomaterials having high biocompatibility, photoluminescence, tunable surface, and hydrophilic property. CDs, therefore, are currently of interest for bio-imaging and nano-medicine applications. In this work, polyethylene glycol functionalized CDs (CD-PEG) were prepared from oil palm empty fruit bunch by a one-pot hydrothermal technique. PEG was chosen as a passivating agent for the enhancement of functionality and photoluminescence properties of CDs. To prepare the CDs-PEG, the effects of temperature, time, and concentration of PEG were investigated on the properties of CDs. The as-prepared CDs-PEG were characterized by several techniques including dynamic light scattering, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, fluorescence spectroscopy, Raman spectroscopy, Fourier-transform infrared spectroscopy and Thermogravimetric analysis. The as-prepared CDs under hydrothermal condition at 220 degrees C for 6 h had spherical morphology with an average diameter of 4.47 nm. Upon modification, CDs-PEG were photo-responsive with excellent photoluminescence property. The CDs-PEG was subsequently used as a drug carrier for doxorubicin [DOX] delivery to CaCo-2, colon cancer cells in vitro. DOX was successfully loaded onto CDs-PEG surface confirmed by FT-IR and Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometer (MALDI-TOF/MS) patterns. The selective treatment of CDs-PEG-DOX against the colorectal cancer cells, , relative to normal human fibroblast cells was succesfully demonstrated. | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.12, no.1, pp.10550 | - |
dc.identifier.doi | 10.1038/s41598-022-14704-x | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.scopusid | 2-s2.0-85132415184 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/60412 | - |
dc.identifier.wosid | 000814836700087 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Facile preparation of aqueous-soluble fluorescent polyethylene glycol functionalized carbon dots from palm waste by one-pot hydrothermal carbonization for colon cancer nanotheranostics | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | TARGETED DRUG-DELIVERY | - |
dc.subject.keywordPlus | DOXORUBICIN HYDROCHLORIDE | - |
dc.subject.keywordPlus | SMALL MOLECULES | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | MATRIX | - |
dc.subject.keywordPlus | QUANTIFICATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | TEMPERATURE | - |
dc.subject.keywordPlus | PYROLYSIS | - |
dc.subject.keywordPlus | EMISSION | - |
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