Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.number | 11 | - |
dc.citation.startPage | 111802 | - |
dc.citation.title | CELL REPORTS | - |
dc.citation.volume | 41 | - |
dc.contributor.author | Hwang, Hyojeong | - |
dc.contributor.author | Yun, Seongmin | - |
dc.contributor.author | Arcanjo, Rachel Braz | - |
dc.contributor.author | Divyanshi | - |
dc.contributor.author | Chen, Sijie | - |
dc.contributor.author | Mei, Wenyan | - |
dc.contributor.author | Nowak, Romana A. | - |
dc.contributor.author | Kwon, Taejoon | - |
dc.contributor.author | Yang, Jing | - |
dc.date.accessioned | 2023-12-21T13:13:51Z | - |
dc.date.available | 2023-12-21T13:13:51Z | - |
dc.date.created | 2022-12-15 | - |
dc.date.issued | 2022-12 | - |
dc.description.abstract | Asymmetric localization of mRNAs is crucial for cell polarity and cell fate determination. By performing fractionation RNA-seq, we report here that a large number of maternal RNAs are associated with the ER in Xenopus oocytes but are released into the cytosol after oocyte maturation. We provide evidence that the majority of ER-associated RNA-binding proteins (RBPs) remain associated with the ER after oocyte maturation. However, all ER-associated RBPs analyzed exhibit reduced binding to some of their target RNAs after oocyte maturation. Our results further show that the ER is remodeled massively during oocyte maturation, leading to the formation of a widespread tubular ER network in the animal hemisphere that is required for the asymmetric localization of mRNAs in mature eggs. Thus, our findings demonstrate that dynamic regulation of RNA-ER association and remodeling of the ER are important for the asymmetric localization of RNAs during development. | - |
dc.identifier.bibliographicCitation | CELL REPORTS, v.41, no.11, pp.111802 | - |
dc.identifier.doi | 10.1016/j.celrep.2022.111802 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.scopusid | 2-s2.0-85143856094 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/60159 | - |
dc.identifier.wosid | 000901764900001 | - |
dc.language | 영어 | - |
dc.publisher | Cell Press | - |
dc.title | Regulation of RNA localization during oocyte maturation by dynamic RNA-ER association and remodeling of the ER | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ENDOPLASMIC-RETICULUM STRUCTURE | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | PROTEIN-SYNTHESIS | - |
dc.subject.keywordPlus | MEIOTIC MATURATION | - |
dc.subject.keywordPlus | STRUCTURAL-CHANGES | - |
dc.subject.keywordPlus | XENOPUS-OOCYTES | - |
dc.subject.keywordPlus | BOUND RIBOSOMES | - |
dc.subject.keywordPlus | GERM PLASM | - |
dc.subject.keywordPlus | TRANSLATION | - |
dc.subject.keywordPlus | REORGANIZATION | - |
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