dc.citation.endPage |
10796 |
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dc.citation.number |
20 |
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dc.citation.startPage |
10792 |
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dc.citation.title |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA |
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dc.citation.volume |
94 |
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dc.contributor.author |
Min, Kyung-Tai |
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dc.contributor.author |
Benzer, S |
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dc.date.accessioned |
2023-12-22T12:37:04Z |
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dc.date.available |
2023-12-22T12:37:04Z |
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dc.date.created |
2014-09-15 |
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dc.date.issued |
1997-09 |
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dc.description.abstract |
Wolbachia, a maternally transmitted micro-organism of the Rickettsial family, is known to cause cytoplasmic incompatibility, parthenogenesis, or feminization in various insect species. The bacterium-host relationship is usually symbiotic: incompatibility between infected males and uninfected females can enhance reproductive isolation and evolution, whereas the other mechanisms enhance progeny production. We have discovered a variant Wolbachia carried by Drosophila melanogaster in which this cozy relationship is abrogated. Although quiescent during the fly's development, it begins massive proliferation in the adult, causing wide-spread degeneration of tissues, including brain, retina, and muscle, culminating in early death. Tetracycline treatment of carrier flies eliminates both the bacteria and the degeneration, restoring normal life-span. The 16s rDNA sequence is over 98% identical to Wolbachia known from other insects. Examination of laboratory strains of D. melanogaster commonly used in genetic experiments reveals that a large proportion actually carry Wolbachia in a nonvirulent form, which might affect their longevity and behavior. |
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dc.identifier.bibliographicCitation |
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.94, no.20, pp.10792 - 10796 |
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dc.identifier.doi |
10.1073/pnas.94.20.10792 |
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dc.identifier.issn |
0027-8424 |
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dc.identifier.scopusid |
2-s2.0-0030987547 |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/6006 |
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dc.identifier.url |
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030987547 |
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dc.identifier.wosid |
A1997XY99800056 |
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dc.language |
영어 |
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dc.publisher |
NATL ACAD SCIENCES |
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dc.title |
Wolbachia, normally a symbiont of Drosophila, can be virulent, causing degeneration and early death |
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dc.type |
Article |
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dc.description.journalRegisteredClass |
scopus |
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