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dc.citation.endPage 10796 -
dc.citation.number 20 -
dc.citation.startPage 10792 -
dc.citation.title PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA -
dc.citation.volume 94 -
dc.contributor.author Min, Kyung-Tai -
dc.contributor.author Benzer, S -
dc.date.accessioned 2023-12-22T12:37:04Z -
dc.date.available 2023-12-22T12:37:04Z -
dc.date.created 2014-09-15 -
dc.date.issued 1997-09 -
dc.description.abstract Wolbachia, a maternally transmitted micro-organism of the Rickettsial family, is known to cause cytoplasmic incompatibility, parthenogenesis, or feminization in various insect species. The bacterium-host relationship is usually symbiotic: incompatibility between infected males and uninfected females can enhance reproductive isolation and evolution, whereas the other mechanisms enhance progeny production. We have discovered a variant Wolbachia carried by Drosophila melanogaster in which this cozy relationship is abrogated. Although quiescent during the fly's development, it begins massive proliferation in the adult, causing wide-spread degeneration of tissues, including brain, retina, and muscle, culminating in early death. Tetracycline treatment of carrier flies eliminates both the bacteria and the degeneration, restoring normal life-span. The 16s rDNA sequence is over 98% identical to Wolbachia known from other insects. Examination of laboratory strains of D. melanogaster commonly used in genetic experiments reveals that a large proportion actually carry Wolbachia in a nonvirulent form, which might affect their longevity and behavior. -
dc.identifier.bibliographicCitation PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.94, no.20, pp.10792 - 10796 -
dc.identifier.doi 10.1073/pnas.94.20.10792 -
dc.identifier.issn 0027-8424 -
dc.identifier.scopusid 2-s2.0-0030987547 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/6006 -
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030987547 -
dc.identifier.wosid A1997XY99800056 -
dc.language 영어 -
dc.publisher NATL ACAD SCIENCES -
dc.title Wolbachia, normally a symbiont of Drosophila, can be virulent, causing degeneration and early death -
dc.type Article -
dc.description.journalRegisteredClass scopus -

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