There are no files associated with this item.
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 2547 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 2539 | - |
dc.citation.title | JACS Au | - |
dc.citation.volume | 2 | - |
dc.contributor.author | Kim, Dohyun | - |
dc.contributor.author | Kim, Sangpil | - |
dc.contributor.author | Park, Gaeun | - |
dc.contributor.author | Choi, Huyeon | - |
dc.contributor.author | Ryu, Ja-Hyoung | - |
dc.date.accessioned | 2023-12-21T13:21:06Z | - |
dc.date.available | 2023-12-21T13:21:06Z | - |
dc.date.created | 2022-11-09 | - |
dc.date.issued | 2022-11 | - |
dc.description.abstract | To achieve spatiotemporal control, an enzyme-instructed self-assembly system is widely used, but this approach typically has a small effect on cellular fate. In this study, we show that the intralysosomal assembly by a carbonic anhydrase IX (CAIX)-targeting peptide amphiphile (Pep-AT) can control cellular fate with a low therapeutic dose by tuning the surface charge based on pH change. Pep-AT self-assembles into a fibrous aggregate with a negative surface charge in an extracellular environment near CAIX. During endocytosis, it changes into a nanofiber with a positive surface charge at the lysosome. Then, it can disrupt the lysosomal membrane and induce cellular apoptosis. This study demonstrates that a spatiotemporal assembly induced by a cancer enzyme and specific organelle can control the cellular fate of cancer. | - |
dc.identifier.bibliographicCitation | JACS Au, v.2, no.11, pp.2539 - 2547 | - |
dc.identifier.doi | 10.1021/jacsau.2c00422 | - |
dc.identifier.issn | 2691-3704 | - |
dc.identifier.scopusid | 2-s2.0-85141943527 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/59990 | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Spatiotemporal Self-Assembly of Peptide Amphiphiles by Carbonic Anhydrase IX-Targeting Induces Cancer-Lysosomal Membrane Disruption | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scopus | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.