Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.startPage | 119675 | - |
dc.citation.title | NEUROIMAGE | - |
dc.citation.volume | 264 | - |
dc.contributor.author | Han, Sohyun | - |
dc.contributor.author | Eun, Seulgi | - |
dc.contributor.author | Cho, Hyungjoon | - |
dc.contributor.author | Uludaq, Kamil | - |
dc.contributor.author | Kim, Seong-Gi | - |
dc.date.accessioned | 2023-12-21T13:15:52Z | - |
dc.date.available | 2023-12-21T13:15:52Z | - |
dc.date.created | 2022-10-18 | - |
dc.date.issued | 2022-12 | - |
dc.description.abstract | The most widely used gradient-echo (GE) blood oxygenation level-dependent (BOLD) contrast has high sensitivity, but low specificity due to draining vein contributions, while spin-echo (SE) BOLD approach at ultra-high magnetic fields is highly specific to neural active sites but has lower sensitivity. To obtain high specificity and sensitivity, we propose to utilize a vessel-size-sensitive filter to the GE-BOLD signal, which suppresses macrovascular contributions and to combine selectively retained microvascular GE-BOLD signals with the SE-BOLD signals. To investigate our proposed idea, fMRI with 0.8 mm isotropic resolution was performed on the primary motor and sensory cortices in humans at 7 T by implementing spin- and gradient-echo (SAGE) echo planar imaging (EPI) acquisition. Microvascular-passed sigmoidal filters were designed based upon the vessel-size-sensitive ΔR2*/ΔR2 value for retaining GE-BOLD signals originating from venous vessels with ≤ 45 μm and ≤ 65 μm diameter. Unlike GE-BOLD fMRI, the laminar profile of SAGE-BOLD fMRI with the vessel-size-sensitive filter peaked at ∼ 1.0 mm from the surface of the primary motor and sensory cortices, demonstrating an improvement of laminar specificity over GE-BOLD fMRI. Also, the functional sensitivity of SAGE BOLD at middle layers (0.75–1.5 mm) was improved by ∼ 80% to ∼100% when compared with SE BOLD. In summary, we showed that combined GE- and SE-BOLD fMRI with the vessel-size-sensitive filter indeed yielded improved laminar specificity and sensitivity and is therefore an excellent tool for high spatial resolution ultra-high filed (UHF)-fMRI studies for resolving mesoscopic functional units. | - |
dc.identifier.bibliographicCitation | NEUROIMAGE, v.264, pp.119675 | - |
dc.identifier.doi | 10.1016/j.neuroimage.2022.119675 | - |
dc.identifier.issn | 1053-8119 | - |
dc.identifier.scopusid | 2-s2.0-85141752822 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/59749 | - |
dc.identifier.wosid | 000892197600005 | - |
dc.language | 영어 | - |
dc.publisher | Academic Press | - |
dc.title | Improved laminar specificity and sensitivity by combining SE and GE BOLD signals | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Neurosciences;Neuroimaging;Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalResearchArea | Neurosciences & Neurology;Radiology, Nuclear Medicine & Medical Imaging | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | High resolution fMRI | - |
dc.subject.keywordAuthor | Ultra-high field | - |
dc.subject.keywordAuthor | Layer specificity and sensitivity | - |
dc.subject.keywordAuthor | Vessel-size-sensitive filter | - |
dc.subject.keywordAuthor | SE BOLD | - |
dc.subject.keywordPlus | SPIN-ECHO BOLD | - |
dc.subject.keywordPlus | OCULAR DOMINANCE COLUMNS | - |
dc.subject.keywordPlus | GRADIENT-ECHO | - |
dc.subject.keywordPlus | FUNCTIONAL MRI | - |
dc.subject.keywordPlus | MAGNETIC-SUSCEPTIBILITY | - |
dc.subject.keywordPlus | HIGH-RESOLUTION | - |
dc.subject.keywordPlus | VESSEL SIZE | - |
dc.subject.keywordPlus | VISUAL-CORTEX | - |
dc.subject.keywordPlus | BLOOD-VOLUME | - |
dc.subject.keywordPlus | HUMAN BRAIN | - |
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