Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 817 | - |
dc.citation.startPage | 807 | - |
dc.citation.title | NATURE CATALYSIS | - |
dc.citation.volume | 5 | - |
dc.contributor.author | Kim, Suk Min | - |
dc.contributor.author | Lee, Jinhee | - |
dc.contributor.author | Kang, Sung Heuck | - |
dc.contributor.author | Heo, Yoonyoung | - |
dc.contributor.author | Yoon, Hye-Jin | - |
dc.contributor.author | Hahn, Ji-Sook | - |
dc.contributor.author | Lee, Hyung Ho | - |
dc.contributor.author | Kim, Yong Hwan | - |
dc.date.accessioned | 2023-12-21T13:41:26Z | - |
dc.date.available | 2023-12-21T13:41:26Z | - |
dc.date.created | 2022-09-21 | - |
dc.date.issued | 2022-09 | - |
dc.description.abstract | Ni–Fe carbon monoxide dehydrogenases (CODHs) are nearly diffusion-limited biocatalysts that oxidize CO. Their O2 sensitivity, however, is a major drawback for industrial applications. Here we compare the structures of a fast CODH with a high O2 sensitivity (ChCODH-II) and a slower CODH with a lower O2 sensitivity (ChCODH-IV) (Ch, Carboxydothermus hydrogenoformans). Some variants obtained by simple point mutations of the bottleneck residue (A559) in the gas tunnel showed 61–148-fold decreases in O2 sensitivity while maintaining high turnover rates. The variant structure A559W showed obstruction of one gas tunnel, and molecular dynamics supported the locked position of the mutated side chain in the tunnel. The variant was exposed to different gas mixtures, from simple synthetic gas to sophisticated real flue from a steel mill. Its catalytic properties remained unchanged, even at high O2 levels, and the efficiency was maintained for multiple cycles of CO detoxification/regeneration. | - |
dc.identifier.bibliographicCitation | NATURE CATALYSIS, v.5, pp.807 - 817 | - |
dc.identifier.doi | 10.1038/s41929-022-00834-y | - |
dc.identifier.issn | 2520-1158 | - |
dc.identifier.scopusid | 2-s2.0-85137854127 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/59716 | - |
dc.identifier.wosid | 000852936800002 | - |
dc.language | 영어 | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | O2-tolerant CO dehydrogenase via tunnel redesign for the removal of CO from industrial flue gas | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | CARBON-MONOXIDE DEHYDROGENASE | - |
dc.subject.keywordPlus | X-RAY CRYSTALLOGRAPHY | - |
dc.subject.keywordPlus | MOLECULAR-DYNAMICS | - |
dc.subject.keywordPlus | ACTIVE-SITE | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | LIFE | - |
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Tel : 052-217-1404 / Email : scholarworks@unist.ac.kr
Copyright (c) 2023 by UNIST LIBRARY. All rights reserved.
ScholarWorks@UNIST was established as an OAK Project for the National Library of Korea.