dc.citation.endPage |
7734 |
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dc.citation.number |
25 |
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dc.citation.startPage |
7732 |
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dc.citation.title |
LANGMUIR |
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dc.citation.volume |
17 |
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dc.contributor.author |
Cho, Yoon-Kyoung |
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dc.contributor.author |
Kim, S |
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dc.contributor.author |
Lim, G |
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dc.contributor.author |
Granick, Steve |
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dc.date.accessioned |
2023-12-22T11:41:11Z |
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dc.date.available |
2023-12-22T11:41:11Z |
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dc.date.created |
2014-09-05 |
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dc.date.issued |
2001-12 |
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dc.description.abstract |
We report the first use of a surface forces apparatus to study the hybridization of DNA. We study the regime of very high ionic strength (≈1 M) at which commercial DNA chip operations are performed. Using a thiol end-attached single-stranded oligonucleotide, we find that exposure to the complementary strand resulted in larger thickness. In addition, the resistance to small-amplitude shear deformations when opposed to a nonadsorbing surface (mica) increased significantly after hybridization. The thickness at onset of significant shear resistance was, for single-stranded DNA, considerably less than that of hybridized DNA. This could provide a new method to detect DNA hybridization efficiency. |
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dc.identifier.bibliographicCitation |
LANGMUIR, v.17, no.25, pp.7732 - 7734 |
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dc.identifier.doi |
10.1021/la0113769 |
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dc.identifier.issn |
0743-7463 |
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dc.identifier.scopusid |
2-s2.0-0035846799 |
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dc.identifier.uri |
https://scholarworks.unist.ac.kr/handle/201301/5914 |
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dc.identifier.url |
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035846799 |
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dc.identifier.wosid |
000172590800006 |
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dc.language |
영어 |
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dc.publisher |
AMER CHEMICAL SOC |
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dc.title |
A surface forces study of DNA hybridization |
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dc.type |
Article |
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dc.description.isOpenAccess |
FALSE |
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dc.description.journalRegisteredClass |
scopus |
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