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Kang, Joo H.
Translational Multiscale Biofluidics Lab (TMB Lab)
Research Interests
  • Biomedical devices, infectious disease, organ-on-a-chip, microfluidics, mechanobiology

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Human cell-camouflaged nanomagnetic scavengers restore immune homeostasis in a rodent model with bacteremia

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Title
Human cell-camouflaged nanomagnetic scavengers restore immune homeostasis in a rodent model with bacteremia
Author
Park, Sung JinKwon, SeyongLee, Min SeokJang, Bong HwanGuzmán-Cedillo, Axel E.Kang, Joo H.
Issue Date
2022-08
Publisher
Wiley - V C H Verlag GmbbH & Co.
Citation
SMALL, pp.2203746
Abstract
Bloodstream infection caused by antimicrobial resistance pathogens is a global concern because it is difficult to treat with conventional therapy. Here, scavenger magnetic nanoparticles enveloped by nanovesicles derived from blood cells (MNVs) are reported, which magnetically eradicate an extreme range of pathogens in an extracorporeal circuit. It is quantitatively revealed that glycophorin A and complement receptor (CR) 1 on red blood cell (RBC)-MNVs predominantly capture human fecal bacteria, carbapenem-resistant (CR) Escherichia coli, and extended-spectrum beta-lactamases-positive (ESBL-positive) E. coli, vancomycin-intermediate Staphylococcus aureus (VISA), endotoxins, and proinflammatory cytokines in human blood. Additionally, CR3 and CR1 on white blood cell-MNVs mainly contribute to depleting the virus envelope proteins of Zika, SARS-CoV-2, and their variants in human blood. Supplementing opsonins into the blood significantly augments the pathogen removal efficiency due to its combinatorial interactions between pathogens and CR1 and CR3 on MNVs. The extracorporeal blood cleansing enables full recovery of lethally infected rodent animals within 7 days by treating them twice in series. It is also validated that parameters reflecting immune homeostasis, such as blood cell counts, cytokine levels, and transcriptomics changes, are restored in blood of the fatally infected rats after treatment.
URI
https://scholarworks.unist.ac.kr/handle/201301/59125
DOI
10.1002/smll.202203746
ISSN
1613-6810
Appears in Collections:
BME_Journal Papers
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