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Jeong, Hoon Eui
Multiscale Biomimetics and Manufacturing Lab.
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dc.citation.endPage 9067 -
dc.citation.number 33 -
dc.citation.startPage 9058 -
dc.citation.title BIOMATERIALS -
dc.citation.volume 35 -
dc.contributor.author Kim, Jangho -
dc.contributor.author Bae, Won-Gyu -
dc.contributor.author Choung, Han-Wool -
dc.contributor.author Lim, Ki Taek -
dc.contributor.author Seonwoo, Hoon -
dc.contributor.author Jeong, Hoon Eui -
dc.contributor.author Suh, Khap-Yang -
dc.contributor.author Jeon, Noo Li -
dc.contributor.author Choung, Pill-Hoon -
dc.contributor.author Chung, Jong Hoon -
dc.date.accessioned 2023-12-22T02:07:28Z -
dc.date.available 2023-12-22T02:07:28Z -
dc.date.created 2014-09-04 -
dc.date.issued 2014-11 -
dc.description.abstract Stem cell-based therapy has been proposed as an enabling alternative not only for the treatment of diseases but also for the regeneration of tissues beyond complex surgical treatments or tissue transplantation. In this study, we approached a conceptual platform that can integrate stem cells into a multiscale patterned substrate for bone regeneration. Inspired by human bone tissue, we developed hierarchically micro- and nanopatterned transplantable patches as synthetic extracellular matrices by employing capillary force lithography in combination with a surface micro-wrinkling method using a poly(lactic-co-glycolic acid) (PLGA) polymer. The multiscale patterned PLGA patches were highly flexible and showed higher tissue adhesion to the underlying tissue than did the single nanopatterned patches. In response to the anisotropically multiscale patterned topography, the adhesion and differentiation of human mesenchymal stem cells (hMSCs) were sensitively controlled. Furthermore, the stem cell patch composed of hMSCs and transplantable PLGA substrate promoted bone regeneration in vivo when both the micro- and nanotopography of the substrate surfaces were synergistically combined. Thus, our study concludes that multiscale patterned transplantable stem cell patches may have a great potential for bone regeneration as well as for various regenerative medicine approaches. -
dc.identifier.bibliographicCitation BIOMATERIALS, v.35, no.33, pp.9058 - 9067 -
dc.identifier.doi 10.1016/j.biomaterials.2014.07.036 -
dc.identifier.issn 0142-9612 -
dc.identifier.scopusid 2-s2.0-84906778972 -
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/5862 -
dc.identifier.url https://www.sciencedirect.com/science/article/pii/S014296121400845X?via%3Dihub -
dc.identifier.wosid 000341674400005 -
dc.language 영어 -
dc.publisher ELSEVIER SCI LTD -
dc.title Multiscale patterned transplantable stem cell patches for bone tissue regeneration -
dc.type Article -
dc.description.isOpenAccess FALSE -
dc.relation.journalWebOfScienceCategory Engineering, Biomedical; Materials Science, Biomaterials -
dc.relation.journalResearchArea Engineering; Materials Science -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -

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