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Jeong, Hoon Eui
Multiscale Biomimetics & Manufacturing Lab
Research Interests
  • Biomimetics
  • Multiscale manufacturing
  • Micro/nanofabrication

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Multiscale patterned transplantable stem cell patches for bone tissue regeneration

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Title
Multiscale patterned transplantable stem cell patches for bone tissue regeneration
Author
Kim, JanghoBae, Won-GyuChoung, Han-WoolLim, Ki TaekSeonwoo, HoonJeong, Hoon EuiSuh, Khap-YangJeon, Noo LiChoung, Pill-HoonChung, Jong Hoon
Issue Date
2014-11
Publisher
ELSEVIER SCI LTD
Citation
BIOMATERIALS, v.35, no.33, pp.9058 - 9067
Abstract
Stem cell-based therapy has been proposed as an enabling alternative not only for the treatment of diseases but also for the regeneration of tissues beyond complex surgical treatments or tissue transplantation. In this study, we approached a conceptual platform that can integrate stem cells into a multiscale patterned substrate for bone regeneration. Inspired by human bone tissue, we developed hierarchically micro- and nanopatterned transplantable patches as synthetic extracellular matrices by employing capillary force lithography in combination with a surface micro-wrinkling method using a poly(lactic-co-glycolic acid) (PLGA) polymer. The multiscale patterned PLGA patches were highly flexible and showed higher tissue adhesion to the underlying tissue than did the single nanopatterned patches. In response to the anisotropically multiscale patterned topography, the adhesion and differentiation of human mesenchymal stem cells (hMSCs) were sensitively controlled. Furthermore, the stem cell patch composed of hMSCs and transplantable PLGA substrate promoted bone regeneration in vivo when both the micro- and nanotopography of the substrate surfaces were synergistically combined. Thus, our study concludes that multiscale patterned transplantable stem cell patches may have a great potential for bone regeneration as well as for various regenerative medicine approaches.
URI
https://scholarworks.unist.ac.kr/handle/201301/5862
URL
https://www.sciencedirect.com/science/article/pii/S014296121400845X?via%3Dihub
DOI
10.1016/j.biomaterials.2014.07.036
ISSN
0142-9612
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