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Cha, Chaenyung
Integrative Biomaterials Engineering
Research Interests
  • Biopolymer, nanocomposites, microfabrication, tissue engineering, drug delivery


Controlling Mechanical Properties of Cell-Laden Hydrogels by Covalent Incorporation of Graphene Oxide

DC Field Value Language Cha, Chaenyung ko Shin, Su Ryon ko Gao, Xiguang ko Annabi, Nasim ko Dokmeci, Mehmet R. ko Tang, Xiaowu (Shirley) ko Khademhosseini, Ali ko 2014-09-11T07:00:58Z - 2014-09-04 ko 2014-02 -
dc.identifier.citation SMALL, v.10, no.3, pp.514 - 523 ko
dc.identifier.issn 1613-6810 ko
dc.identifier.uri -
dc.identifier.uri ko
dc.description.abstract Graphene-based materials are useful reinforcing agents to modify the mechanical properties of hydrogels. Here, an approach is presented to covalently incorporate graphene oxide (GO) into hydrogels via radical copolymerization to enhance the dispersion and conjugation of GO sheets within the hydrogels. GO is chemically modified to present surface-grafted methacrylate groups (MeGO). In comparison to GO, higher concentrations of MeGO can be stably dispersed in a pre-gel solution containing methacrylated gelatin (GelMA) without aggregation or significant increase in viscosity. In addition, the resulting MeGO-GelMA hydrogels demonstrate a significant increase in fracture strength with increasing MeGO concentration. Interestingly, the rigidity of the hydrogels is not significantly affected by the covalently incorporated GO. Therefore, this approach can be used to enhance the structural integrity and resistance to fracture of the hydrogels without inadvertently affecting their rigidity, which is known to affect the behavior of encapsulated cells. The biocompatibility of MeGO-GelMA hydrogels is confirmed by measuring the viability and proliferation of the encapsulated fibroblasts. Overall, this study highlights the advantage of covalently incorporating GO into a hydrogel system, and improves the quality of cell-laden hydrogels. ko
dc.description.statementofresponsibility close -
dc.language ENG ko
dc.publisher WILEY-V C H VERLAG GMBH ko
dc.subject Cell encapsulations ko
dc.subject Chemically modified ko
dc.subject Encapsulated cell ko
dc.subject Graphene oxides ko
dc.subject Methacrylate groups ko
dc.subject methacrylated gelatin (GelMA) ko
dc.subject Radical copolymerization ko
dc.subject Reinforcing agent ko
dc.title Controlling Mechanical Properties of Cell-Laden Hydrogels by Covalent Incorporation of Graphene Oxide ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-84893490707 ko
dc.identifier.wosid 000331944300013 ko
dc.type.rims ART ko
dc.description.wostc 9 *
dc.description.scopustc 1 * 2015-05-06 * 2014-09-04 *
dc.identifier.doi 10.1002/smll.201302182 ko
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