Full metadata record
DC Field | Value | Language |
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dc.citation.endPage | 6204 | - |
dc.citation.number | 21 | - |
dc.citation.startPage | 6197 | - |
dc.citation.title | CHEMICAL SCIENCE | - |
dc.citation.volume | 13 | - |
dc.contributor.author | Choi, Huyeon | - |
dc.contributor.author | Park, Gaeun | - |
dc.contributor.author | Shin, Eunhye | - |
dc.contributor.author | Shin, Seon Woo | - |
dc.contributor.author | Jana, Batakrishna | - |
dc.contributor.author | Jin, Seongeon | - |
dc.contributor.author | Kim, Sangpil | - |
dc.contributor.author | Wang, Huaimin | - |
dc.contributor.author | Kwak, Sang Kyu | - |
dc.contributor.author | Xu, Bing | - |
dc.contributor.author | Ryu, Ja-Hyoung | - |
dc.date.accessioned | 2023-12-21T14:15:48Z | - |
dc.date.available | 2023-12-21T14:15:48Z | - |
dc.date.created | 2022-05-13 | - |
dc.date.issued | 2022-04 | - |
dc.description.abstract | Mitochondria are essential intracellular organelles involved in many cellular processes, especially adenosine triphosphate (ATP) production. Since cancer cells require high ATP levels for proliferation, ATP elimination can be a unique target for cancer growth inhibition. We describe a newly developed mitochondria-targeting nucleopeptide (MNP) that sequesters ATP by self-assembling with ATP inside mitochondria. MNP interacts strongly with ATP through electrostatic and hydrogen bonding interactions. MNP exhibits higher binding affinity for ATP (-637.5 kJ mol(-1)) than for adenosine diphosphate (ADP) (-578.2 kJ mol(-1)). To improve anticancer efficacy, the small-sized MNP/ADP complex formed large assemblies with ATP inside cancer cell mitochondria. ATP sequestration and formation of large assemblies of the MNP/ADP-ATP complex inside mitochondria caused physical stress by large structures and metabolic disorders in cancer cells, leading to apoptosis. This work illustrates a facile approach to developing cancer therapeutics that relies on molecular assemblies. | - |
dc.identifier.bibliographicCitation | CHEMICAL SCIENCE, v.13, no.21, pp.6197 - 6204 | - |
dc.identifier.doi | 10.1039/d1sc05738c | - |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.scopusid | 2-s2.0-85129973468 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/58433 | - |
dc.identifier.url | https://pubs.rsc.org/en/content/articlelanding/2022/SC/D1SC05738C | - |
dc.identifier.wosid | 000788179600001 | - |
dc.language | 영어 | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Intramitochondrial co-assembly between ATP and nucleopeptides induces cancer cell apoptosis | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalRegisteredClass | scie | - |
dc.subject.keywordPlus | TARGETING MITOCHONDRIA | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | METABOLISM | - |
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