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Cho, Yoon-Kyoung
Integrated Nano-Biotech Lab (INBL)
Research Interests
  • Microfluidics, Lab-on-a-chip, personalized biomedical diagnostics, nanobioengineering

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Recent advances in spheroid-based microfluidic models to mimic the tumour microenvironment

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Title
Recent advances in spheroid-based microfluidic models to mimic the tumour microenvironment
Author
Ro, JooyoungKim, JunyoungCho, Yoon-Kyoung
Issue Date
2022-04
Publisher
ROYAL SOC CHEMISTRY
Citation
ANALYST
Abstract
Three-dimensional (3D) multicellular spheroid models can recapitulate the human tumour microenvironment with more accuracy than conventional cell culture models, as they include complex architectural structures and dynamic cellular interactions. Among the diverse platforms for spheroid formation, microfluidic platforms have been extensively applied to study spheroids because they can mimic the in vivo microenvironment. This review provides an overview of the advantages of 3D spheroid cultures with a summary of the recent applications for tumour microenvironment-focused cellular interactions, as well as the studies on spheroids and external stimuli. These 3D tumour spheroid-based microfluidic devices will provide a platform for a better understanding of cellular and external interactions, as well as the discovery of cancer therapeutics.
URI
https://scholarworks.unist.ac.kr/handle/201301/58402
URL
https://pubs.rsc.org/en/content/articlelanding/2022/AN/D2AN00172A
DOI
10.1039/d2an00172a
ISSN
0003-2654
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BME_Journal Papers
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