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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 43 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 36 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 444 | - |
dc.contributor.author | Yoon, Haejin | - |
dc.contributor.author | Shin, Seung-Hyun | - |
dc.contributor.author | Shin, Dong Hoon | - |
dc.contributor.author | Chun, Yang-Sook | - |
dc.contributor.author | Park, Jong-Wan | - |
dc.date.accessioned | 2023-12-22T03:07:28Z | - |
dc.date.available | 2023-12-22T03:07:28Z | - |
dc.date.created | 2022-03-08 | - |
dc.date.issued | 2014-01 | - |
dc.description.abstract | Hypoxia-inducible factors 1 alpha and 2 alpha (H1F-1 alpha and HIF-2 alpha) determine cancer cell fate under hypoxia. Despite the similarities of their structures, HIF-1 alpha and HIF-2 alpha have distinct roles in cancer growth under hypoxia, that is, HIF-1 alpha induces growth arrest whereas HIF-2 alpha promotes cell growth. Recently, sirtuin 1 (Sirt1) was reported to fine-tune cellular responses to hypoxia by deacetylating HIF-1 alpha and HIF-2 alpha. Yet, the roles of Sirt1 in HIF-1 alpha and HIF-2 alpha functions have been controversial. We here investigated the precise roles of Sirt1 in HIF-1 alpha and HIF-2 alpha regulations. Immunological analyses revealed that HIF-lot K674 and HIF-2 alpha K741 are acetylated by PCAF and CBP, respectively, but are deacetylated commonly by Sirt1. In the Gal4 reporter systems, Sirt1 was found to repress HIF-la activity constantly in ten cancer cell-lines but to regulate HIF-2 alpha activity cell type-dependently. Moreover, Sirt1 determined cell growth under hypoxia depending on HIF-1 alpha and HIF-2 alpha. Under hypoxia, Sirt1 promoted cell proliferation of HepG2, in which Sirt1 differentially regulates HIF-1 alpha and HIF-2 alpha. In contrast, such an effect of Sirt1 was not shown in HCT116, in which Sirt1 inactivates both HIF-1 alpha and HIF-2 alpha because conflicting actions of HIF-1 alpha and HIF-2 alpha on cell growth may be offset. Our results provide a better understanding of the roles of Sirt1 in HIF-mediated hypoxic responses and also a basic concept for developing anticancer strategy targeting Sirt1. (C) 2014 Elsevier Inc. All rights reserved. | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.444, no.1, pp.36 - 43 | - |
dc.identifier.doi | 10.1016/j.bbrc.2014.01.001 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.scopusid | 2-s2.0-84893830924 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/58172 | - |
dc.identifier.wosid | 000331689000007 | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Differential roles of Sirt1 in HIF-1 alpha and HIF-2 alpha mediated hypoxic responses | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology; Biophysics | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology; Biophysics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Sirtuin 1 | - |
dc.subject.keywordAuthor | Lysine acetylation | - |
dc.subject.keywordAuthor | Hypoxia | - |
dc.subject.keywordAuthor | Hypoxia-inducible factors | - |
dc.subject.keywordAuthor | Transcriptional activity | - |
dc.subject.keywordPlus | INDUCIBLE FACTOR 1-ALPHA | - |
dc.subject.keywordPlus | CELL-CYCLE ARREST | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | SIRTUINS | - |
dc.subject.keywordPlus | MYC | - |
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