Forgetting to take medicine would not be a problem if it were released internally when your body signaled a need for it. Advances in sensors, implants, telemetry, and microfabrication are leading us in that direction. Sapna K. Deo, Elissavet A. Moschou, Serban F. Peteu, Leonidas G. Bachas, and Sylvia Daunert at the University of Kentucky; Patricia E. Eisenhardt at ChipRx; and Marc J. Madou at the University of California - Irvine describe how personal pharmaceutical delivery systems might work.