Full metadata record
DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 4666 | - |
dc.citation.startPage | 4659 | - |
dc.citation.title | Clinical Ophthalmology | - |
dc.citation.volume | 15 | - |
dc.contributor.author | Chao, Daniel L | - |
dc.contributor.author | Rinella, Nicolas T | - |
dc.contributor.author | Khanani, Arshad M | - |
dc.contributor.author | Wykoff, Charles C | - |
dc.contributor.author | Kim, Gun-Ho | - |
dc.date.accessioned | 2023-12-21T14:46:01Z | - |
dc.date.available | 2023-12-21T14:46:01Z | - |
dc.date.created | 2022-03-28 | - |
dc.date.issued | 2021-12 | - |
dc.description.abstract | Purpose: To evaluate the safety and efficacy of a novel medical device to provide cooling anesthesia to the eye as local anesthesia for intravitreal injections. Study Design: First in human, open-label study of 43 subjects assessed at three different doses: −10°C for 20 seconds (group 1), −15°C for 15 seconds (group 2), and −15°C for 20 seconds (group 3). Main outcome measures were safety and pain of injection using a numeric rating scale (NRS). Results: Cooling anesthesia did not result in any serious ocular adverse events. One grade 1 adverse event was a vasovagal response during cooling administration which resolved immediately after cooling. Mean NRS scores at the time of injection for each group ranged from 2.5 to 4.3 There was a statistically significant difference between pain scores of the 3 groups at injection in aggregate but not in pairwise comparisons (P value = 0.047). There was a statistically significant decrease in pain from injection to 5 minutes post injection in all groups (P value = 0.00008, 0.003, 0.0005 for groups 1, 2, 3, respectively) as well as from 5 minutes to 24–48 hours (P value = 0.00001, 0.018, and 0.0545 for groups 1, 2, 3, respectively). Conclusion: The rapid cooling anesthesia device was well tolerated for achieving local anesthesia among patients receiving intravitreal injections with no serious ocular adverse events. | - |
dc.identifier.bibliographicCitation | Clinical Ophthalmology, v.15, pp.4659 - 4666 | - |
dc.identifier.doi | 10.2147/opth.s336653 | - |
dc.identifier.issn | 1177-5467 | - |
dc.identifier.scopusid | 2-s2.0-85123556136 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/57686 | - |
dc.language | 영어 | - |
dc.publisher | Dove Medical Press Ltd | - |
dc.title | Cooling Anesthesia for Intravitreal Injection: Results of the Prospective Open-Label, Dose-Ranging COOL-1 Trial | - |
dc.type | Article | - |
dc.description.isOpenAccess | TRUE | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | Anesthesia | - |
dc.subject.keywordAuthor | Cooling | - |
dc.subject.keywordAuthor | Intravitreal injection | - |
dc.subject.keywordAuthor | Pain | - |
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