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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 1455 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1448 | - |
dc.citation.title | BIOMATERIALS SCIENCE | - |
dc.citation.volume | 10 | - |
dc.contributor.author | Oh, Jun Yong | - |
dc.contributor.author | Yang, Gyeongseok | - |
dc.contributor.author | Choi, Eunshil | - |
dc.contributor.author | Ryu, Ja-Hyoung | - |
dc.date.accessioned | 2023-12-21T14:38:00Z | - |
dc.date.available | 2023-12-21T14:38:00Z | - |
dc.date.created | 2022-03-18 | - |
dc.date.issued | 2022-02 | - |
dc.description.abstract | For efficient drug delivery, stable encapsulation of a large amount of anticancer drugs is crucial, not to mention cell-specific delivery. Among many possible nanocarriers, mesoporous silica nanoparticles are versatile frameworks that satisfy those requirements owing to their characteristic internal pores with a large surface area and a tunable surface composition. By using a noncovalent post-modification strategy, MSN-based drug delivery systems with enhanced therapeutic efficiency can be prepared in a simple one-pot process by loading small anticancer drugs in the unmodified mesopores and by subsequently blocking the drug-loaded pores with a stimuli-responsive polymer gatekeeper. For targeted delivery, drug-loaded MSNs can be functionalized with suitable targeting components such as targeting ligands or artificial protein corona. This mini-review highlights the recent research in which MSN-supported nanocarriers are designed, synthesized, and characterized to possess a high drug loading capacity and encapsulation stability along with targeting capability for more efficient cancer treatment. | - |
dc.identifier.bibliographicCitation | BIOMATERIALS SCIENCE, v.10, no.6, pp.1448 - 1455 | - |
dc.identifier.doi | 10.1039/d2bm00010e | - |
dc.identifier.issn | 2047-4830 | - |
dc.identifier.scopusid | 2-s2.0-85126830634 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/57680 | - |
dc.identifier.url | https://pubs.rsc.org/en/content/articlelanding/2022/BM/D2BM00010E | - |
dc.identifier.wosid | 000762397400001 | - |
dc.language | 영어 | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Mesoporous silica nanoparticle-supported nanocarriers with enhanced drug loading, encapsulation stability, and targeting efficiency | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.type.docType | Review; Early Access | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | POLY(ETHYLENE GLYCOL) | - |
dc.subject.keywordPlus | BIOMOLECULE CORONA | - |
dc.subject.keywordPlus | CO-DELIVERY | - |
dc.subject.keywordPlus | GATEKEEPERS | - |
dc.subject.keywordPlus | SORAFENIB | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | PH | - |
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