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DC Field | Value | Language |
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dc.citation.number | 9 | - |
dc.citation.startPage | e2103532119 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 119 | - |
dc.contributor.author | Kwon, Taejoon | - |
dc.contributor.author | Ra, Jae Sun | - |
dc.contributor.author | Lee, Soyoung | - |
dc.contributor.author | Baek, In-Joon | - |
dc.contributor.author | Khim, Keon Woo | - |
dc.contributor.author | Lee, Eun A | - |
dc.contributor.author | Song, Eun Kyung | - |
dc.contributor.author | Otarbayev, Daniyar | - |
dc.contributor.author | Jung, Woojae | - |
dc.contributor.author | Park, Yong Hwan | - |
dc.contributor.author | Wie, Minwoo | - |
dc.contributor.author | Bae, Juyoung | - |
dc.contributor.author | Cheng, Himchan | - |
dc.contributor.author | Park, Jun Hong | - |
dc.contributor.author | Kim, Namwoo | - |
dc.contributor.author | Seo, Yuri | - |
dc.contributor.author | Yun, Seongmin | - |
dc.contributor.author | Kim, Ha Eun | - |
dc.contributor.author | Moon, Hyo Eun | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.contributor.author | Park, Tae Joo | - |
dc.contributor.author | Park, Young Un | - |
dc.contributor.author | Rhee, Hwanseok | - |
dc.contributor.author | Choi, Jang Hyun | - |
dc.contributor.author | Cho, Seung Woo | - |
dc.contributor.author | Myung, Kyungjae | - |
dc.date.accessioned | 2023-12-21T14:36:53Z | - |
dc.date.available | 2023-12-21T14:36:53Z | - |
dc.date.created | 2022-02-26 | - |
dc.date.issued | 2022-03 | - |
dc.description.abstract | An ideal cancer therapeutic strategy involves the selective killing of cancer cells without affecting the surrounding normal cells. However, researchers have failed to develop such methods for achieving selective cancer cell death because of shared features between cancerous and normal cells. In this study, we have developed a therapeutic strategy called the cancer-specific insertions–deletions (InDels) attacker (CINDELA) to selectively induce cancer cell death using the CRISPR-Cas system. CINDELA utilizes a previously unexplored idea of introducing CRISPR-mediated DNA double-strand breaks (DSBs) in a cancer-specific fashion to facilitate specific cell death. In particular, CINDELA targets multiple InDels with CRISPR-Cas9 to produce many DNA DSBs that result in cancer-specific cell death. As a proof of concept, we demonstrate here that CINDELA selectively kills human cancer cell lines, xenograft human tumors in mice, patient-derived glioblastoma, and lung patient-driven xenograft tumors without affecting healthy human cells or altering mouse growth. | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.119, no.9, pp.e2103532119 | - |
dc.identifier.doi | 10.1073/pnas.2103532119 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.scopusid | 2-s2.0-85125550068 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/57307 | - |
dc.identifier.url | https://www.pnas.org/content/119/9/e2103532119 | - |
dc.identifier.wosid | 000766705700004 | - |
dc.language | 영어 | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9 | - |
dc.type | Article | - |
dc.description.isOpenAccess | FALSE | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | CRISPR | - |
dc.subject.keywordAuthor | insertion | - |
dc.subject.keywordAuthor | deletion | - |
dc.subject.keywordAuthor | cancer | - |
dc.subject.keywordAuthor | double-strand breaks | - |
dc.subject.keywordPlus | GENOME-WIDE | - |
dc.subject.keywordPlus | DNA-REPAIR | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | SEQUENCE | - |
dc.subject.keywordPlus | INSERTION | - |
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