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Kim, Donghyuk
Systems Biology and Machine Learning Lab.
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dc.citation.number 1 -
dc.citation.startPage 1569 -
dc.citation.title SCIENTIFIC REPORTS -
dc.citation.volume 12 - Kyung, Su Min - Choi, Sung-Woon - Lim, Jaewon - Shim, Soojin - Kim, Suji - Im, Young Bin - Lee, Na-Eun - Hwang, Cheol-Yong - Kim, Donghyuk - Yoo, Han Sang - 2023-12-21T14:41:41Z - 2023-12-21T14:41:41Z - 2022-02-11 - 2022-01 -
dc.description.abstract Carbapenems are broad-spectrum antibiotics widely used for the treatment of human infections caused by multidrug-resistant (MDR) Gram-negative bacteria. However, emerging carbapenemase-producing Enterobacterales (CPE) are rising as a public threat to human and animal health. We screened clinical bacterial isolates from 241 dogs and 18 cats hospitalized at Veterinary Medical Teaching Hospital, Seoul National University, from 2018 to 2020 for carbapenemase production. In our study, 5 strains of metallo-beta-lactamase NDM-5-producing Escherichia coli and Klebsiella pneumoniae were isolated from 4 different dogs. Multilocus sequence typing (MLST) results showed that all E. coli strains were ST410 and all K. pneumoniae strains were ST378. Whole genome analysis of the plasmid showed that bla(NDM-5) is carried on a IncX3 plasmid, showing a high concordance rate with plasmids detected worldwide in human and animal isolates. The bla(NDM) gene was associated with the ble(MBL) gene and the ISAba125 element, truncated with the IS5 element. The results of this study show that CPE has already become as a threat to both animals and humans in our society, posing the necessity to solve it in terms of "One Health". Therefore, preventive strategies should be developed to prevent the spread of CPE in animal and human societies. -
dc.identifier.bibliographicCitation SCIENTIFIC REPORTS, v.12, no.1, pp.1569 -
dc.identifier.doi 10.1038/s41598-022-05585-1 -
dc.identifier.issn 2045-2322 -
dc.identifier.scopusid 2-s2.0-85123855624 -
dc.identifier.uri -
dc.identifier.url -
dc.identifier.wosid 000749357900030 -
dc.language 영어 -
dc.publisher NATURE PORTFOLIO -
dc.title Comparative genomic analysis of plasmids encoding metallo-beta-lactamase NDM-5 in Enterobacterales Korean isolates from companion dogs -
dc.type Article -
dc.description.isOpenAccess TRUE -
dc.relation.journalWebOfScienceCategory Multidisciplinary Sciences -
dc.relation.journalResearchArea Science & Technology - Other Topics -
dc.type.docType Article -
dc.description.journalRegisteredClass scie -
dc.description.journalRegisteredClass scopus -
dc.subject.keywordPlus KLEBSIELLA-PNEUMONIAE -
dc.subject.keywordPlus ESCHERICHIA-COLI -
dc.subject.keywordPlus CARRYING BLA(NDM-5) -
dc.subject.keywordPlus GENES -
dc.subject.keywordPlus IDENTIFICATION -
dc.subject.keywordPlus OXA-181 -
dc.subject.keywordPlus PCR -


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