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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C


A role for nuclear phospholipase C beta(1) in cell cycle control

DC Field Value Language Faenza, I ko Matteucci, A ko Manzoli, L ko Billi, AM ko Aluigi, M ko Peruzzi, D ko Vitale, M ko Castorina, S ko Suh, Pann-Ghill ko Cocco, L ko 2014-09-04T00:41:27Z - 2014-09-02 ko 2000-09 ko
dc.identifier.citation JOURNAL OF BIOLOGICAL CHEMISTRY, v.275, no.39, pp.30520 - 30524 ko
dc.identifier.issn 0021-9258 ko
dc.identifier.uri -
dc.description.abstract Phosphoinositide signaling resides in the nucleus, and among the enzymes of the cycle, phospholipase C (PLC) appears as the key element both in Saccharomyces cerevisiae and in mammalian cells. The yeast PLC pathway produces multiple inositol polyphosphates that modulate distinct nuclear processes. The mammalian PLC beta(1), which localizes in the nucleus, is activated in insulin-like growth factor 1-mediated mitogenesis and undergoes down-regulation during murine erythroleukemia differentiation. PLC beta(1) exists as two polypeptides of 150 and 140 kDa generated from a single gene by alternative RNA splicing, both of them containing in the COOH-terminal tail a cluster of lysine residues responsible for nuclear localization. These clues prompted us to try to establish the critical nuclear target(s) of PLC beta(1) subtypes in the control of cell cycle progression. The results reveal that the two subtypes of PLC beta(1) that localize in the nucleus induce cell cycle progression in Friend erythroleukemia cells. In fact when they are overexpressed in the nucleus, cyclin D3, along with its kinase (cdk4) but not cyclin E is overexpressed even though cells are serum-starved. As a consequence of this enforced expression, retinoblastoma protein is phosphorylated and E2F-1 transcription factor is activated as well. On the whole the results reveal a direct effect of nuclear PLC beta(1) signaling in G(1) progression by means of a specific target, i.e. cyclin D3/cdk4. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.title A role for nuclear phospholipase C beta(1) in cell cycle control ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0034730764 ko
dc.identifier.wosid 000089577900082 ko
dc.type.rims ART ko
dc.description.wostc 116 *
dc.description.scopustc 115 * 2015-05-06 * 2014-09-02 *
dc.identifier.doi 10.1074/jbc.M004630200 ko
dc.identifier.url ko
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