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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 822 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 816 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 282 | - |
dc.contributor.author | Hong, Feng | - |
dc.contributor.author | Moon, Keunai | - |
dc.contributor.author | Kim, Samsoo | - |
dc.contributor.author | Kim, Youngseol | - |
dc.contributor.author | Choi, Youngkil | - |
dc.contributor.author | Bae, Yunsoo | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Ryu, Sungho | - |
dc.contributor.author | Choi, Euiju | - |
dc.contributor.author | Ha, Joohun | - |
dc.contributor.author | Kim, Sungsoo | - |
dc.date.accessioned | 2023-12-22T11:45:07Z | - |
dc.date.available | 2023-12-22T11:45:07Z | - |
dc.date.created | 2014-09-02 | - |
dc.date.issued | 2001-04 | - |
dc.description.abstract | Insulin-like growth factor-I (IGF-I) regulates muscle differentiation through phosphatidylinositol 3-kinase (PI 3-kinase), Also it was recently reported that PI 3-kinase is involved in the activation of phospholipase C-gamma1 (PLC-gamma1), We investigated whether PLC-gamma1 therefore plays a role in IGF-I-induced muscle differentiation using H9c2 rat cardiac myoblasts as a model. IGF-I was able to activate PLC-gamma1 via both PI3-kinase-dependent and tyrosine phosphorylation-dependent mechanisms in this model. However, PI 3-kinase appeared to play a more important role than tyrosine phosphorylation in IGF-I activation of PLC-gamma1, In addition, PLC-gamma1. activation was independent of Akt/ protein kinase B (Akt/PKB), Importantly, PLC-gamma1 was involved in IGF-I-induced muscle differentiation in parallel with Akt/PKB, Taken together, these results suggest that IGF-I regulation of muscle differentiation is dependent on the activation of PLC-gamma1 and Akt/PKB, both of which are downstream mediators of PI 3-kinase. | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.282, no.3, pp.816 - 822 | - |
dc.identifier.doi | 10.1006/bbrc.2001.4644 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.scopusid | 2-s2.0-0034814451 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/5693 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0034814451 | - |
dc.identifier.wosid | 000168092000027 | - |
dc.language | 영어 | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Role of phospholipase C-gamma 1 in insulin-like growth factor I-induced muscle differentiation of H9c2 cardiac myoblasts | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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