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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C


Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE

DC Field Value Language Ye, KQ ko Aghdasi, B ko Luo, HBR ko Moriarity, JL ko Wu, FY ko Hong, JJ ko Hurt, KJ ko Bae, SS ko Suh, Pann-Ghill ko Snyder, SH ko 2014-09-04T00:41:20Z - 2014-09-02 ko 2002-01 ko
dc.identifier.citation NATURE, v.415, no.6871, pp.541 - 544 ko
dc.identifier.issn 0028-0836 ko
dc.identifier.uri -
dc.description.abstract Phospholipase Cgamma1 (PLC-gamma1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-gamma1 also has mitogenic activity upon growth-factor-dependent tyrosine phophorylation(1,2); however, this activity is not dependent on the phospholipase activity of PLC-gamma1, but requires an SH3 domain(3,4). Here, we demonstrate that PLC-gamma1 acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer). PIKE is a nuclear GTPase that activates nuclear PI(3)K activity, and mediates the physiological activation by nerve growth factor (NGF) of nuclear PI(3)K activity(5). This enzymatic activity accounts for the mitogenic properties of PLC-gamma1. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.title Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0037203868 ko
dc.identifier.wosid 000173564300050 ko
dc.type.rims ART ko
dc.description.wostc 119 *
dc.description.scopustc 125 * 2015-05-06 * 2014-09-02 *
dc.identifier.doi 10.1038/415541a ko
dc.identifier.url ko
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