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Suh, Pann-Ghill
BioSignal Network Lab (BSN)
Research Interests
  • Signal transduction, cancer, metabolism, phospholipase C

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Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE

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dc.contributor.author Ye, KQ ko
dc.contributor.author Aghdasi, B ko
dc.contributor.author Luo, HBR ko
dc.contributor.author Moriarity, JL ko
dc.contributor.author Wu, FY ko
dc.contributor.author Hong, JJ ko
dc.contributor.author Hurt, KJ ko
dc.contributor.author Bae, SS ko
dc.contributor.author Suh, Pann-Ghill ko
dc.contributor.author Snyder, SH ko
dc.date.available 2014-09-04T00:41:20Z -
dc.date.created 2014-09-02 ko
dc.date.issued 2002-01 ko
dc.identifier.citation NATURE, v.415, no.6871, pp.541 - 544 ko
dc.identifier.issn 0028-0836 ko
dc.identifier.uri https://scholarworks.unist.ac.kr/handle/201301/5691 -
dc.description.abstract Phospholipase Cgamma1 (PLC-gamma1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-gamma1 also has mitogenic activity upon growth-factor-dependent tyrosine phophorylation(1,2); however, this activity is not dependent on the phospholipase activity of PLC-gamma1, but requires an SH3 domain(3,4). Here, we demonstrate that PLC-gamma1 acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer). PIKE is a nuclear GTPase that activates nuclear PI(3)K activity, and mediates the physiological activation by nerve growth factor (NGF) of nuclear PI(3)K activity(5). This enzymatic activity accounts for the mitogenic properties of PLC-gamma1. ko
dc.description.statementofresponsibility close -
dc.language 영어 ko
dc.publisher NATURE PUBLISHING GROUP ko
dc.title Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE ko
dc.type ARTICLE ko
dc.identifier.scopusid 2-s2.0-0037203868 ko
dc.identifier.wosid 000173564300050 ko
dc.type.rims ART ko
dc.description.wostc 119 *
dc.description.scopustc 125 *
dc.date.tcdate 2015-05-06 *
dc.date.scptcdate 2014-09-02 *
dc.identifier.doi 10.1038/415541a ko
dc.identifier.url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037203868 ko
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