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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 541 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 529 | - |
dc.citation.title | CELL | - |
dc.citation.volume | 111 | - |
dc.contributor.author | Patterson, RL | - |
dc.contributor.author | van Rossum, DB | - |
dc.contributor.author | Ford, DL | - |
dc.contributor.author | Hurt, KJ | - |
dc.contributor.author | Bae, SS | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Kurosaki, T | - |
dc.contributor.author | Snyder, SH | - |
dc.contributor.author | Gill, DL | - |
dc.date.accessioned | 2023-12-22T11:36:38Z | - |
dc.date.available | 2023-12-22T11:36:38Z | - |
dc.date.created | 2014-09-02 | - |
dc.date.issued | 2002-11 | - |
dc.description.abstract | We report here that PLC-γ isoforms are required for agonist-induced Ca2+ entry (ACE). Overexpressed wild-type PLC-γ1 or a lipase-inactive mutant PLC-γ1 each augmented ACE in PC12 cells, while a deletion mutant lacking the region containing the SH3 domain of PLC-γ1 was ineffective. RNA interference to deplete either PLC-γ1 or PLC-γ2 in PC12 and A7r5 cells inhibited ACE. In DT40 B lymphocytes expressing only PLC-γ2, overexpressed muscarinic M5 receptors (M5R) activated ACE. Using DT40 PLC-γ2 knockout cells, M5R stimulation of ER Ca2+ store release was unaffected, but ACE was abolished. Normal ACE was restored by transient expression of PLC-γ2 or a lipase-inactive PLC-γ2 mutant. The results indicate a lipase-independent role of PLC-γ in the physiological agonist-induced activation of Ca2+ entry. | - |
dc.identifier.bibliographicCitation | CELL, v.111, no.4, pp.529 - 541 | - |
dc.identifier.doi | 10.1016/S0092-8674(02)01045-0 | - |
dc.identifier.issn | 0092-8674 | - |
dc.identifier.scopusid | 2-s2.0-0037112160 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/5685 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037112160 | - |
dc.identifier.wosid | 000179346900006 | - |
dc.language | 영어 | - |
dc.publisher | CELL PRESS | - |
dc.title | Phospholipase C-gamma is required for agonist-induced Ca2+ entry | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
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