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Park, Jongnam
Materials and Chemistry Lab (MCL)
Research Interests
  • Inorganic synthesis, microfluidics, nanomaterials, surface engineering, bioimaging

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Charge-Modulated Synthesis of Highly Stable Iron Oxide Nanoparticles for In Vitro and In Vivo Toxicity Evaluation

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Title
Charge-Modulated Synthesis of Highly Stable Iron Oxide Nanoparticles for In Vitro and In Vivo Toxicity Evaluation
Author
Woo, SunyoungKim, SoojinKim, HyunhongCheon, Young WooYoon, SeokjooOh, Jung-HwaPark, Jongnam
Issue Date
2021-11
Publisher
MDPI
Citation
NANOMATERIALS, v.11, no.11
Abstract
The surface charge of iron oxide nanoparticles (IONPs) plays a critical role in the interactions between nanoparticles and biological components, which significantly affects their toxicity in vitro and in vivo. In this study, we synthesized three differently charged IONPs (negative, neutral, and positive) based on catechol-derived dopamine, polyethylene glycol, carboxylic acid, and amine groups, via reversible addition–fragmentation chain transfer-mediated polymerization (RAFT polymerization) and ligand exchange. The zeta potentials of the negative, neutral, and positive IONPs were −39, −0.6, and +32 mV, respectively, and all three IONPs showed long-term colloidal stability for three months in an aqueous solution without agglomeration. The cytotoxicity of the IONPs was studied by analyzing cell viability and morphological alteration in three human cell lines, A549, Huh-7, and SH-SY5Y. Neither IONP caused significant cellular damage in any of the three cell lines. Furthermore, the IONPs showed no acute toxicity in BALB/c mice, in hematological and histological analyses. These results indicate that our charged IONPs, having high colloidal stability and biocompatibility, are viable for bio-applications
URI
https://scholarworks.unist.ac.kr/handle/201301/56591
URL
https://www.mdpi.com/2079-4991/11/11/3068
DOI
10.3390/nano11113068
ISSN
2079-4991
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BME_Journal Papers
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