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DC Field | Value | Language |
---|---|---|
dc.citation.endPage | 34075 | - |
dc.citation.number | 49 | - |
dc.citation.startPage | 34069 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 283 | - |
dc.contributor.author | Cha, Sun-Shin | - |
dc.contributor.author | Il Jung, Ha | - |
dc.contributor.author | Jeon, Hyesung | - |
dc.contributor.author | An, Young Jun | - |
dc.contributor.author | Kim, In-Kwon | - |
dc.contributor.author | Yun, Sanguk | - |
dc.contributor.author | Ahn, Hyun Jin | - |
dc.contributor.author | Chung, Kwang Chul | - |
dc.contributor.author | Lee, Sang Hee | - |
dc.contributor.author | Suh, Pann-Ghill | - |
dc.contributor.author | Kang, Sa-Ouk | - |
dc.date.accessioned | 2023-12-22T08:14:52Z | - |
dc.date.available | 2023-12-22T08:14:52Z | - |
dc.date.created | 2014-09-02 | - |
dc.date.issued | 2008-12 | - |
dc.description.abstract | Mutations in the DJ-1 gene have been implicated in the autosomal recessive early onset parkinsonism. DJ-1 is a soluble dimeric protein with critical roles in response to oxidative stress and in neuronal maintenance. However, several lines of evidence suggest the existence of a nonfunctional aggregated form of DJ-1 in the brain of patients with some neurodegenerative diseases. Here, we show that inorganic phosphate, an important anion that exhibits elevated levels in patients with Parkinson disease, transforms DJ-1 into filamentous aggregates. According to the 2.4-A crystal structure, DJ-1 dimers are linearly stacked through Pi-mediated interactions to form protofilaments, which are then bundled into a filamentous assembly. | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.283, no.49, pp.34069 - 34075 | - |
dc.identifier.doi | 10.1074/jbc.M804243200 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.scopusid | 2-s2.0-57749116309 | - |
dc.identifier.uri | https://scholarworks.unist.ac.kr/handle/201301/5654 | - |
dc.identifier.url | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=57749116309 | - |
dc.identifier.wosid | 000261277700035 | - |
dc.language | 영어 | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | Crystal Structure of Filamentous Aggregates of Human DJ-1 Formed in an Inorganic Phosphate-dependent Manner | - |
dc.type | Article | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | FAMILIAL PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | MULTIPLE SYSTEM ATROPHY | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | DROSOPHILA DJ-1 | - |
dc.subject.keywordPlus | ALPHA-SYNUCLEIN | - |
dc.subject.keywordPlus | PROTEIN DJ-1 | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | FERTILITY | - |
dc.subject.keywordPlus | L166P | - |
dc.subject.keywordPlus | INACTIVATION | - |
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